1-(1-ethylpiperidin-4-yl)-1H-pyrazole-4-amine | 1246551-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-ethylpiperidin-4-yl)-1H-pyrazole-4-amine
• 英文别名: 1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-amine；1-(1-ethylpiperidin-4-yl)pyrazol-4-amine
• CAS: 1246551-22-3
• 化学式: C₁₀H₁₈N₄
• 分子量: 194.28
• InChiKey: DFZAUMQUZBXWEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(1-ethylpiperidin-4-yl)-1H-pyrazole-4-amine 以26 %的产率得到7-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-3-(5-(5-(2-methoxyphenyl)-1H-imidazol-2-yl)-2-methylphenyl)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
  参考文献：
  名称：

  7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME

  摘要：

  本公开涉及一种7-氨基-3,4-二氢嘧啶嘧啶-2-酮衍生物化合物，其对癌细胞具有出色的抗增殖作用，其药学上可接受的盐，水合物或立体异构体，其生产方法，包含其作为活性成分的用于预防，缓解或治疗癌症转移和增殖性疾病的药物组合物，以及针对癌细胞的抗癌组合物。该化合物表现出优异的癌细胞抑制活性和抗增殖效果，因此在抑制癌细胞，预防癌症转移和增殖性疾病或治疗癌症方面具有有效性。

  公开号：

  EP4092029A1

文献信息

• Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：US11518758B2

  公开（公告）日：2022-12-06

  Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

  本文描述的化合物是自噬抑制剂，可用于治疗癌症等疾病。
• HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：US20200354346A1

  公开（公告）日：2020-11-12

  Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.
• [EN] 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] DÉRIVÉ DE 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE AYANT UNE ACTIVITÉ INHIBITRICE VIS-À-VIS DES PROTÉINES KINASES ET COMPOSITION PHARMACEUTIQUE THÉRAPEUTIQUE COMPRENANT CELUI-CI<br/>[KO] 단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물
  申请人：KOREA INST SCI & TECH

  公开号：WO2021145520A1

  公开（公告）日：2021-07-22

  본 발명은 암세포에 대한 우수한 항 증식 효능을 나타내는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 화합물, 이의 약학적으로 허용 가능한 염, 이의 수화물 또는 이의 입체 이성질체와, 이의 제조 방법 및 이를 유효성분으로 함유하는 암 전이 및 증식성 질환의 예방, 경감 또는 치료용 약학 조성물, 및 암세포에 대한 항암 조성물에 관한 것으로서, 상기 화합물은 우수한 암세포 억제 활성 및 항증식 효능을 나타내므로, 암세포 저해는 물론이고 나아가 암 전이 및 증식성 질환의 예방 또는 암 치료에 유용하다.
• 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Korea Institute of Science and Technology

  公开号：EP4092029A1

  公开（公告）日：2022-11-23

  The present disclosure relates to a 7-amino-3,4-dihydropyrimidopyrimidin-2-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anti-cancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.

  本公开涉及一种7-氨基-3,4-二氢嘧啶嘧啶-2-酮衍生物化合物，其对癌细胞具有出色的抗增殖作用，其药学上可接受的盐，水合物或立体异构体，其生产方法，包含其作为活性成分的用于预防，缓解或治疗癌症转移和增殖性疾病的药物组合物，以及针对癌细胞的抗癌组合物。该化合物表现出优异的癌细胞抑制活性和抗增殖效果，因此在抑制癌细胞，预防癌症转移和增殖性疾病或治疗癌症方面具有有效性。