N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol | 324759-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol
• 英文别名: N-7-oxanonyl-6-methyldeoxygalactonolirimycin；UT-231B free base；(2R,3S,4R,5S)-1-(6-ethoxyhexyl)-2-methylpiperidine-3,4,5-triol
• CAS: 324759-98-0
• 化学式: C₁₄H₂₉NO₄
• 分子量: 275.389
• InChiKey: BBIRATBJZBAXFS-ZOBORPQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  73.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol 在 盐酸 作用下， 以 水 为溶剂， 反应 3.0h， 以99%的产率得到N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol hydrochloride salt
  参考文献：
  名称：

  LONG CHAIN N-ALKYL COMPOUNDS AND OXA-DERIVATIVES THEREOF AND USE AS ANTIVIRAL COMPOSITIONS

  摘要：

  公开号：

  EP1210082B1
• 作为产物：
  描述：

  N-nonyl-1,5,6-trideoxy-1,5-imino-3,4-O-isopropylidene D-galactitol 在 三氟乙酸 作用下， 以 水 为溶剂， 反应 2.0h， 以96%的产率得到N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol
  参考文献：
  名称：

  LONG CHAIN N-ALKYL COMPOUNDS AND OXA-DERIVATIVES THEREOF AND USE AS ANTIVIRAL COMPOSITIONS

  摘要：

  公开号：

  EP1210082B1

文献信息

• ANTIVIRAL PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20090275535A1

  公开（公告）日：2009-11-05

  The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  这项发明涉及具有抗病毒活性的磷取代化合物，包含这种化合物的组合物以及包括给予这种化合物的治疗方法，还包括用于制备这种化合物的过程和中间体。
• Long chain N-alkyl compounds and oxa-derivatives thereof
  申请人：Zitzmann Nicole

  公开号：US20100137365A1

  公开（公告）日：2010-06-03

  Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C 8 -C 16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
• Long chain N-Alkyl compounds and oxa-derivatives thereof
  申请人：Zitzmann Nicole

  公开号：US20110184019A1

  公开（公告）日：2011-07-28

  Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C 8 -C 16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
• US7256005B2
  申请人：——

  公开号：US7256005B2

  公开（公告）日：2007-08-14
• US7429565B2
  申请人：——

  公开号：US7429565B2

  公开（公告）日：2008-09-30