picrasidine O | 101219-63-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吲哚萘啶生物碱
• 英文名称: picrasidine O
• 英文别名: 4-methoxy-6-methyl-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-4,7,9(16),10,12,14-hexaene-2,3-dione
• CAS: 101219-63-0
• 化学式: C₁₆H₁₂N₂O₃
• 分子量: 280.283
• InChiKey: HPAUUBGCMSMJQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  DL-色氨酸 反应 0.33h， 生成 picrasidine O
  参考文献：
  名称：

  Koike, Kazuo; Yoshino, Hiroshi; Nikaido, Tamotsu, Heterocycles, 1999, vol. 51, # 2, p. 315 - 323

  摘要：

  DOI：

文献信息

• Studies on the alkaloids from Picrasma quassioides Bennet. VI. Structures of picrasidines N, O, and Q.
  作者：TAICHI OHMOTO、KAZUO KOIKE

  DOI：10.1248/cpb.33.4901

  日期：——

  Three new alkaloids, picrasidines N (I), O (II), and Q (III), have been isolated from the root wood of Picrasma quassioides BENNET (Simaroubaceae). The structures were determined on the basis of spectral analysis and chemical evidence.

  从 Picrasma quassioides BENNET（樗树科）的根木中分离出了三种新生物碱，即苦木碱 N (I)、O (II) 和 Q (III)。根据光谱分析和化学证据确定了它们的结构。
• Novel Nature-Inspired Anticancer and Antibacterial Motifs and Pharmaceutical Composition Thereof
  申请人：University of Sharjah

  公开号：US20210317121A1

  公开（公告）日：2021-10-14

  There is provided novel anticancer and antibacterial compounds, pharmaceutically acceptable salts thereof, and processes for their preparation. The compounds have anticancer activity, which results in the reduction of tumour cell proliferation, enhances cancers cells apoptosis and regulation of iron signalling. The compounds are also particularly active against various Gram-negative and Gram-positive multidrug-resistant bacteria, such as extended-spectrum beta-lactamase (ESBL) producing and colistin-resistant Escherichia coli , carbapenem-resistant E. coli , carbapenem-resistant Acinetobacter baumannii , and methicillin-resistant Staphylococcus aureus (MRSA) including those with reduced susceptibility to many control antibiotics.