1-Methoxy-4-trityloxy-benzene | 20705-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-Methoxy-4-trityloxy-benzene
• 英文别名: Benzene, 1-methoxy-4-(trityloxy)-；1-methoxy-4-trityloxybenzene
• CAS: 20705-45-7
• 化学式: C₂₆H₂₂O₂
• 分子量: 366.459
• InChiKey: KBUDNFPVYKDUSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methoxy-4-trityloxy-benzene 在 四氢呋喃 、 titanium(III) chloride 、 lithium 作用下， 反应 10.0h， 以68%的产率得到4-甲氧基苯酚
  参考文献：
  名称：

  LOW-VALENT TITANIUM MEDIATED REDUCTIVE CLEAVAGE OFO/N-TRITYL BONDS VIA FREE RADICAL PATHWAY

  摘要：

  Low-valent titanium mediated cleavage of trityl-O/N bonds in trityl ethers/amines via electron transfer process is reported. Chemoselective deprotection of trityl ethers in preference to benzyl ethers is achieved. The ease of cleavage of protected alcohols and amines is in the order O-allyl > O-trityl > O-benzyl; N-trityl > O-trityl bonds.

  DOI：

  10.1081/scc-120014795
• 作为产物：
  描述：

  三苯基氯甲烷 、 4-甲氧基苯酚 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-Methoxy-4-trityloxy-benzene
  参考文献：
  名称：

  LOW-VALENT TITANIUM MEDIATED REDUCTIVE CLEAVAGE OFO/N-TRITYL BONDS VIA FREE RADICAL PATHWAY

  摘要：

  Low-valent titanium mediated cleavage of trityl-O/N bonds in trityl ethers/amines via electron transfer process is reported. Chemoselective deprotection of trityl ethers in preference to benzyl ethers is achieved. The ease of cleavage of protected alcohols and amines is in the order O-allyl > O-trityl > O-benzyl; N-trityl > O-trityl bonds.

  DOI：

  10.1081/scc-120014795

文献信息

• LOW-VALENT TITANIUM MEDIATED REDUCTIVE CLEAVAGE OF<i>O/N</i>-TRITYL BONDS VIA FREE RADICAL PATHWAY
  作者：Shyam Rele、Sandip K. Nayak

  DOI：10.1081/scc-120014795

  日期：2002.1

  Low-valent titanium mediated cleavage of trityl-O/N bonds in trityl ethers/amines via electron transfer process is reported. Chemoselective deprotection of trityl ethers in preference to benzyl ethers is achieved. The ease of cleavage of protected alcohols and amines is in the order O-allyl > O-trityl > O-benzyl; N-trityl > O-trityl bonds.