tetrabutylphosphine bromide | 64267-87-4

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: tetrabutylphosphine bromide
• 英文别名: Bromo(tetrabutyl)-lambda5-phosphane；bromo(tetrabutyl)-λ5-phosphane
• CAS: 64267-87-4
• 化学式: C₁₆H₃₆BrP
• 分子量: 339.34
• InChiKey: ZTGKRWWWUGCLHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  tetrabutylphosphine bromide 生成 (tetrabutyl-λ5-phosphanyl) 2-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]propanoate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  Tributylbutylidenphosphoran 、 特戊醛 、 氢溴酸 、 四氢呋喃 以5%的产率得到
  参考文献：
  名称：

  MARYANOFF B. E.; REITZ A. B.; MUTTER M. S.; INNERS R. R.; ALMOND H. R.; W+, J. AMER. CHEM. SOC., 108,(1986) N 24, 7664-7678

  摘要：

  DOI：

文献信息

• Alcohol Dehydration
  申请人：Wass Duncan Frank

  公开号：US20100267996A1

  公开（公告）日：2010-10-21

  Catalyst compositions are disclosed exhibiting activity for dehydrating an alcohol, the composition comprising a source of a Group VIII transition metal, an organic salt, an acid and/or a compound consisting of a conjugate base of an acid bonded to a radical of the alcohol to be dehydrated and, optionally, a ligand. Also disclosed are methods of converting an alcohol into a product using the catalyst composition. The product of the methods may be predominately alkene or ether depending on the method. In some embodiments of the method a second catalyst for converting a product into a further product may be present.

  揭示了催化剂组合物，具有脱水醇的活性，该组合物包括第VIII族过渡金属的来源、有机盐、酸和/或由酸的共轭碱与待脱水醇的基团结合而成的化合物，以及可选的配体。还揭示了利用该催化剂组合物将醇转化为产品的方法。根据该方法，方法的产物可能主要是烯烃或醚，具体取决于方法。在某些方法的实施中，可能存在第二种催化剂，用于将产物转化为进一步的产物。
• METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN
  申请人：2Y-CHEM, LTD.

  公开号：US20150274728A1

  公开（公告）日：2015-10-01

  The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing a compound V which is an important intermediate of linagliptin and has the structure V, and an industrial process of preparing linagliptin having excellent chemical and optical purities, which is an inhibitor of dipeptidyl peptidase-4 (DPP-IV), from the compound V. The process employs a phase-transfer catalyst, is high in yield, easy and simple to handle, environmentally friendly, suitable for industrial mass production, and can be implemented by a “one-pot process”.

  本发明公开了一种改进的制备利那格列汀重要中间体的工艺。具体公开了一种制备化合物V的工艺，该化合物V是利那格列汀的重要中间体，具有结构V，并且从化合物V中制备出具有优异化学和光学纯度的利那格列汀的工业工艺，利那格列汀是二肽基肽酶-4（DPP-IV）的抑制剂。该工艺采用相转移催化剂，产率高，易于操作和简单处理，环保，适合工业大规模生产，并且可以通过“一锅法”实施。
• PROCESS FOR REGIOSELECTIVE DEMETHYLATION OF P-METHOXY GROUP IN PHENOLIC ESTER AND DIARYL KETONE MOIETIES
  申请人：Negi Singh Arvind

  公开号：US20060052463A1

  公开（公告）日：2006-03-09

  Demethylation of 3′,4′-dimethoxy or 3′,4′,5′-trimethoxy benzoic ester of a phenol is carried out in the presence of an excess of aluminum halide in an organic solvent to get 4′-Hydroxy, 3′-methoxy or 4′ hydroxy, 3′,5′-dimethoxy benzoic acid ester of a phenol. The reaction is also applicable to 3′,4′,5′-trimethoxy diaryl ketone and some natural products like reserpine.

  苯酚的3′,4′-二甲氧基或3′,4′,5′-三甲氧基苯甲酸酯的去甲基化是在有机溶剂中过量使用铝卤化物的情况下进行的，以得到苯酚的4′-羟基，3′-甲氧基或4′羟基，3′,5′-二甲氧基苯甲酸酯。该反应也适用于3′,4′,5′-三甲氧基二芳基酮和一些天然产物，如利血平。
• Acrylic monomer composition, acrylic copolymer, and heat resistant resin
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP0987282A2

  公开（公告）日：2000-03-22

  A heat resistant resin is formed by heating an acrylic monomer composition prepared by copolymerising an acrylic monomer represented by general formula (1) with another monomer that is copolymerisable with the acrylic monomer, the acrylic monomer composition having an acid value of 5mgKOH/g or less, where each of R1 and R2 is either a hydrogen atom or an organic residue. A 1% tetrahydrofuran solution formed by subjecting the acrylic copolymer to a heat treatment at a temperature of 250°C for 30minutes and thereafter dissolving the acrylic copolymer in tetrahydrofuran has a viscosity ranging from 10cps to 10,000cps at 25°C. The acrylic polymer does not gel in the manufacture of a heat resistant resin, and by using the acrylic polymer as a material for a heat resistant resin, the resultant heat resistant resin obtained boasts excellent transparency and mouldability, and can be moulded by melting.

  通过加热由通式（1）代表的丙烯酸单体与可与该丙烯酸单体共聚的另一种单体共聚制备的丙烯酸单体组合物，形成耐热树脂，该丙烯酸单体组合物的酸值为 5mgKOH/g 或更低、 其中 R1 和 R2 均为氢原子或有机残基。将丙烯酸共聚物在 250℃的温度下热处理 30 分钟，然后将丙烯酸共聚物溶解在四氢呋喃中，形成的 1%四氢呋喃溶液在 25℃时的粘度为 10cps 至 10,000cps。在制造耐热树脂时，丙烯酸聚合物不会凝胶，使用丙烯酸聚合物作为耐热树脂的材料，得到的耐热树脂具有良好的透明度和成型性，可以通过熔化成型。
• Polyalkoxyalkyl (meth)acrylates and preparation thereof
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1254922A2

  公开（公告）日：2002-11-06

  To provide a biocompatible material with a high level of safety at a low cost. The biocompatible material has a polymer synthesized from monomers by an anionic polymerization, wherein the polymer has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) in a range of 1.0 to 1.5, in which the weight-average molecular weight is 40,000 or more, and each of the monomers is represented by a following general formula (1): where R1 is a hydrogen atom or a methyl group; R2 is a C1-C4 alkylene group; and R3 is a C1-C4 alkyl group. The anionic polymerization may proceed in the presence of a tertiary aluminium compound.

  提供一种低成本、高安全性的生物相容性材料。该生物相容性材料具有一种由单体通过阴离子聚合法合成的聚合物，其中聚合物的重量平均分子量（Mw）与数均分子量（Mn）之比（Mw/Mn）在 1.0 至 1.5 的范围内，其中重量平均分子量为 40,000 或更高，且每种单体由以下通式（1）表示： 其中 R1 是氢原子或甲基；R2 是 C1-C4 亚烷基；R3 是 C1-C4 烷基。 阴离子聚合可在叔铝化合物存在下进行。

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