(-)-cis-2-hydroxymethyl-4-(5'-azacytosin-1'-yl)-1,3-dioxolane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: (-)-cis-2-hydroxymethyl-4-(5'-azacytosin-1'-yl)-1,3-dioxolane
• 英文别名: 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,3,5-triazin-2-one
• 化学式: C₇H₁₀N₄O₄
• 分子量: 214.181
• InChiKey: CTXKCMMIADCIJP-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 palladium(II) oxide 、 环己烯 、 1,3-丙二醇 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 (-)-cis-2-hydroxymethyl-4-(5'-azacytosin-1'-yl)-1,3-dioxolane
  参考文献：
  名称：

  Synthesis and biological evaluation of l- and d-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides

  摘要：

  Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)- 1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against HBV, whereas the D-configuration analogue (14) has been found to exhibit potent anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00418-2

文献信息

• Method for the treatment or prevention of Flaviviridea viral infection using nucleoside analogues
  申请人：BioChem Pharma Inc.

  公开号：US20030225037A1

  公开（公告）日：2003-12-04

  In accordance with the present invention there is provided a method for treating or preventing a Flaviviridea viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) 1 or or a pharmaceutically acceptable salts thereof, wherein Ra, R, Z and Y are defined in the application.

  根据本发明，提供了一种用于治疗或预防宿主中的Flavivirideaviral感染的方法，包括给予至少一种式(I)或(II)1或它们的药学上可接受的盐的治疗有效量，其中Ra、R、Z和Y在申请中有定义。
• DIOXOLANE NUCLEOSIDE ANALOGS FOR THE TREATMENT OR PREVENTION OF VIRAL INFECTION
  申请人：Shire BioChem Inc.

  公开号：EP1214074B1

  公开（公告）日：2004-06-16
• METHOD FOR THE TREATMENT OR PREVENTION OF i FLAVIVIRIDAE /i VIRAL INFECTION USING NUCLEOSIDE ANALOGUES
  申请人：BIOCHEM PHARMA INC

  公开号：EP1225899A2

  公开（公告）日：2002-07-31
• Method for the treatment or prevention of viral infection using nucleoside analogues
  申请人：BioChem Pharma Inc.

  公开号：US20040014757A1

  公开（公告）日：2004-01-22

  The present invention relates to uses and methods for treating or preventing a viral infection selected from the group consisting of herpes simple virus, varicella zoster virus, respiratory syncytial virus and cytomegalovirus in a host comprising using a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof. The present invention also includes pharmaceutical compositions and combinations.
• US6566365B1
  申请人：——

  公开号：US6566365B1

  公开（公告）日：2003-05-20