N-(4-acetyl-1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide | 60644-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(4-acetyl-1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide
• 英文别名: N-[4-acetyl-1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide；Propanamide, N-(4-acetyl-1-(2-phenylethyl)-4-piperidinyl)-N-phenyl-；N-[4-acetyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide
• CAS: 60644-99-7
• 化学式: C₂₄H₃₀N₂O₂
• 分子量: 378.514
• InChiKey: QWGNBDHHZUUXTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Acetyl-4-anilino-1-(2-phenylethyl)-piperidin 生成 N-(4-acetyl-1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide
  参考文献：
  名称：

  Piperidin-4-spiro-oxiranes

  摘要：

  提供了公式（I）的新型哒啶-4-螺-环氧烷化合物，可用于合成各种苯胺基哒啶化合物。这些新型化合物可以从4-取代哒啶酮和苯基亚砜或砜烯起始原料在一个锅反应中合成。使用这些新型化合物可以在比以往已知方法更少的阶段内生产苯胺基哒啶。

  公开号：

  US05420280A1

文献信息

• ISOTOPICALLY LABELED CHEMICALLY STABLE REAGENTS AND PROCESS FOR THE SYNTHESIS THEREOF
  申请人：PerkinElmer Health Sciences, Inc.

  公开号：US20130030184A1

  公开（公告）日：2013-01-31

  A radioisotope labeled reagent includes a compound having the general formula (I), L-( a C b H 2 ) n a C b H 3 (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R 1 SO 2 —O—, R 1 —S—, 12 C 1 H 3 ( 12 C 3 H 2 ) n—S—R 1 C(O)O—, NC—, (R 1 ) 3 P—, XMg—and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R 1 is H, aryl, a substituent containing aryl, C 1 -C 20 alkyl, a substituent containing C 1 -C 20 alkyl, C 2 -C 20 alkenyl, a substitute containing C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, and a substitute containing C 2 -C 20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R 1 in R 1 —S is not aryl.
• MEDICATED SPRAY FOR TREATMENT OF SUBSTANCE ABUSE, OVERDOSE, ADDICTION AND IMPULSE CONTROL DISORDERS
  申请人：GOOBERMAN Lance L.

  公开号：US20200352917A1

  公开（公告）日：2020-11-12

  A method to treat carfentanyl overdose comprising administrating a pharmaceutical formulation in the form of liquid solution for spray administration by the nasal and/or buccal route containing naltrexone as active ingredient in amounts greater than 1%.
• US3998834A
  申请人：——

  公开号：US3998834A

  公开（公告）日：1976-12-21
• US4179569A
  申请人：——

  公开号：US4179569A

  公开（公告）日：1979-12-18
• US5420280A
  申请人：——

  公开号：US5420280A

  公开（公告）日：1995-05-30