α-高野尻霉素 | 119557-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: α-高野尻霉素
• 中文别名: Alpha-高野尻霉素；Α-高野尻霉素
• 英文名称: (2r,3r,5s,6r)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triol
• CAS: 119557-99-2
• 化学式: C₇H₁₅NO₅
• 分子量: 193.2
• InChiKey: CLVUFWXGNIFGNC-QTSLKERKSA-N

物化性质

• 熔点：
  207 °C
• 沸点：
  432.0±45.0 °C(Predicted)
• 密度：
  1.479±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Method for the treatment of Pompe disease using 1-deoxynojirimycin and derivatives
  申请人：Mugrage Benjamin

  公开号：US20060264467A1

  公开（公告）日：2006-11-23

  The present invention provides a method for increasing the activity of a mutant or wild-type α-glucosidase enzyme in vitro and in vivo by contacting the enzyme with a specific pharmacological chaperone which is a derivative of 1-deoxynojirimycin. The invention also provides a method for the treatment of Pompe disease by administration of chaperone small molecule compound which is a derivative of 1-deoxynojirimycin. The 1-deoxynojirimycin derivative is substituted at the N or C1 position. Combination therapy with replacement α-glucosidase gene or enzyme is also provided.

  本发明提供了一种通过将酶与一种特定的药理伴侣接触来增加体外和体内突变型或野生型α葡萄糖苷酶酶活性的方法，该药理伴侣是1-去氧诺吉霉素的衍生物。该发明还提供了一种通过给予1-去氧诺吉霉素衍生物的伴侣小分子化合物来治疗庞贝病的方法。1-去氧诺吉霉素衍生物在N或C1位置被取代。还提供了与替代α葡萄糖苷酶基因或酶的联合治疗方法。
• Salts of creatine imino sugar amides
  申请人：Heuer Marvin A.

  公开号：US20090298877A1

  公开（公告）日：2009-12-03

  The present invention relates to stable salts of creatine imino sugar amides and an inorganic or organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral and parenteral administration. Methods of preparation and use of these compositions are also provided.

  本发明涉及肌酸亚胺糖酰胺的稳定盐和一种无机或有机酸，具有增强的营养和/或治疗功效，相对于它们各自的效应，并且包含这些盐的固体组合物，特别适用于口服和静脉注射。还提供了这些组合物的制备和使用方法。
• Preparations containing creatine and imino sugars
  申请人：Heuer Marvin A.

  公开号：US20090297685A1

  公开（公告）日：2009-12-03

  Compounds produced by combining imino sugars and creatine are herein disclosed. The compounds being in the form of a creatine imino sugar amides and produced by the disclosed methods; protecting the guanidine group of creatine and then activating the protected creatine with DCC and reacting it with an imino sugar, followed by removal of the guanidine protecting groups. The resulting creatine imino sugar amides have enhanced stability in solution as compared to related esters. In addition, specific benefits are conferred by the imino sugar in addition to, and separate from, the creatine substituent. Methods of preparation and use of these compounds are also disclosed.

  本文公开了通过合并亚胺糖和肌酸而产生的化合物。该化合物以肌酸亚胺糖酰胺的形式存在，并通过所公开的方法制备；先保护肌酸的胍基团，然后用DCC激活保护的肌酸并与亚胺糖反应，随后去除胍基保护基团。与相关酯相比，所得到的肌酸亚胺糖酰胺在溶液中具有增强的稳定性。此外，亚胺糖还赋予特定的益处，除了与肌酸取代基分离外。本文还公开了这些化合物的制备和使用方法。
• GLYCOSIDASE INHIBITORS AND USES THEREOF
  申请人：Alectos Therapeutics Inc.

  公开号：US20150299122A1

  公开（公告）日：2015-10-22

  The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

  本发明提供了抑制糖苷酶的化合物，该化合物的前药，以及包括该化合物或该化合物的前药的制药组合物。本发明还提供了治疗与O-GlcNA酶的缺乏或过度表达、O-GlcNAc的积累或缺乏有关的疾病和障碍的方法。
• A METHOD FOR THE TREATMENT OF POMPE DISEASE USING 1-DEOXYNOJIRIMYCIN AND DERIVATIVES
  申请人：Amicus Therapeutics, Inc.

  公开号：EP1896083A2

  公开（公告）日：2008-03-12