(R)-tert-Butyl 3-cyclopropaneamidopiperidine-1-carboxylate | 1286207-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (R)-tert-Butyl 3-cyclopropaneamidopiperidine-1-carboxylate
• 英文别名: tert-butyl (3R)-3-(cyclopropanecarbonylamino)piperidine-1-carboxylate
• CAS: 1286207-31-5
• 化学式: C₁₄H₂₄N₂O₃
• 分子量: 268.356
• InChiKey: DJLFKWRLNWWOGT-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-tert-Butyl 3-cyclopropaneamidopiperidine-1-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 、 乙酸乙酯 为溶剂， 生成 (R)-N-(piperidin-3-yl)cyclopropanecarboxamide
  参考文献：
  名称：

  Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

  摘要：

  Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.068
• 作为产物：
  描述：

  (R)-(-)-1-Boc-3-氨基哌啶 、 环丙基甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-tert-Butyl 3-cyclopropaneamidopiperidine-1-carboxylate
  参考文献：
  名称：

  Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

  摘要：

  Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.068

文献信息

• Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands
  作者：Guiying Li、Hao Zhou、Yu Jiang、Holger Keim、Sidney W. Topiol、Suresh B. Poda、Yong Ren、Gamini Chandrasena、Darío Doller

  DOI：10.1016/j.bmcl.2010.12.068

  日期：2011.2

  Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon. (C) 2010 Elsevier Ltd. All rights reserved.