5-氨基-2-哌啶-1-苯胺 | 50891-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 5-氨基-2-哌啶-1-苯胺
• 英文名称: 5-Amino-2-piperidin-1-yl-benzamide
• 英文别名: 5-amino-2-piperidin-1-ylbenzamide
• CAS: 50891-33-3
• 化学式: C₁₂H₁₇N₃O
• mdl: MFCD03042683
• 分子量: 219.286
• InChiKey: LUAYPIWXMDEQHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  1-(2,4-Dimethylbenzenesulfonyl)piperidine-4-carboxylic acid 、 5-氨基-2-哌啶-1-苯胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 N-(3-carbamoyl-4-piperidin-1-ylphenyl)-1-(2,4-dimethylphenyl)sulfonylpiperidine-4-carboxamide
  参考文献：
  名称：

  Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors

  摘要：

  A series of potent amide non-urea inhibitors of soluble epoxide hydrolase (sEH) is disclosed. The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs. Structure-activities studies guided optimization of a lead compound, identified through high-throughput screening, gave rise to sub-nanomolar inhibitors of human sEH with stability in human liver microsomal assay suitable for preclinical development. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.11.084

文献信息

• PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION
  申请人：L'OREAL

  公开号：US20160143826A1

  公开（公告）日：2016-05-26

  The present invention relates to a process for dyeing human keratin fibres, in which use is made of one or more metal catalysts and a composition (A) comprising: (a) at least 10% by weight of one or more fatty substances, (b) one or more oxidation bases of formula (I) or (II), the addition salts thereof, solvates thereof and mixtures thereof: Formula (I), Formula (II) (c) one or more chemical oxidizing agents other than atmospheric oxygen. The invention also relates to a multi-compartment device and to a composition comprising all of the above-mentioned ingredients.
• US9872822B2
  申请人：——

  公开号：US9872822B2

  公开（公告）日：2018-01-23
• Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors
  作者：Stevan Pecic、Svetlana Pakhomova、Marcia E. Newcomer、Christophe Morisseau、Bruce D. Hammock、Zhengxiang Zhu、Alison Rinderspacher、Shi-Xian Deng

  DOI：10.1016/j.bmcl.2012.11.084

  日期：2013.1

  A series of potent amide non-urea inhibitors of soluble epoxide hydrolase (sEH) is disclosed. The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs. Structure-activities studies guided optimization of a lead compound, identified through high-throughput screening, gave rise to sub-nanomolar inhibitors of human sEH with stability in human liver microsomal assay suitable for preclinical development. Published by Elsevier Ltd.