8-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-3-one | 116515-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯嗪
• 英文名称: 8-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-3-one
• 英文别名: 5,6,7,7a-tetrahydro-3h-pyrrolizin-7a-ol-3-one；3H-Pyrrolizin-3-one, 5,6,7,7a-tetrahydro-7a-hydroxy-；8-hydroxy-6,7-dihydro-5H-pyrrolizin-3-one
• CAS: 116515-49-2
• 化学式: C₇H₉NO₂
• 分子量: 139.154
• InChiKey: UHWVDQANLORLJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,3-二氢-1H-吡咯里嗪-7-羧酸 在 rose bengal 、 C.I.酸性橙108 作用下， 以 甲醇 为溶剂， 反应 5.25h， 生成 8-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-3-one
  参考文献：
  名称：

  Gadaginamath, Guru S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 955 - 956

  摘要：

  DOI：

文献信息

• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• A Solvent Effect That Influences the Preparative Utility of <i>N</i>-(Silylalkyl)phthalimide and <i>N</i>-(Silylalkyl)maleimide Photochemistry
  作者：Ung Chan Yoon、Sun Wha Oh、Soo Min Lee、Sung Ju Cho、Janet Gamlin、Patrick S. Mariano

  DOI：10.1021/jo990087a

  日期：1999.6.1

  The photochemistry of selected N-silylalkyl-substituted phthalimides and maleimides has been investigated with the aim of exploring the generality and preparative consequences of an intriguing solvent effect on excited-state reaction chemoselectivities and quantum efficiencies. An example of this effect is found in the photochemistry of N-[(trimethylsilyl)butyl]phthalimide 10, where irradiation in MeCN leads to production of a mixture of four products that arise by excited-state intramolecular hydrogen-atom abstraction. In contrast, the benzoindolizidine 15 is the sole product produced by a single electron transfer (SET)-desilylation pathway upon irradiation of 10 in 35% H2O-MeCN. Another example of this solvent effect is found in the photochemistry of the N-silylpropyl-maleimide 17. Irradiation in MeCN results in the production of the 2+2-dimer 19 whereas the pyrrolizidine 18 is generated exclusively by irradiation of 17 in 35% H2O-MeCN. The results of fluorescence and triplet sensitization experiments suggest that the solvent effect has multiple sources including the control of the nature, reactivity, and intrinsic lifetimes of singlet and triplet excited states of the phthalimide and maleimide systems. The exploratory studies have clearly demonstrated the generality of this solvent effect and how it can be used to enhance the preparative utility of the photochemistry of N-(silylalkyl)phthalimides and N-(silylalkyl)maleimides.
• GADAGINAMATH, GURU S., INDIAN J. CHEM., 26,(1987) N 10, 955-956
  作者：GADAGINAMATH, GURU S.

  DOI：——

  日期：——
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：enEvolv, Inc.

  公开号：EP3027754A1

  公开（公告）日：2016-06-08
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17