8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctan-1-ol | 136949-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctan-1-ol
• 英文别名: 2-[N-[2-[N-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-2,4-dinitroanilino]ethyl]-2,4-dinitroanilino]ethanol
• CAS: 136949-87-6
• 化学式: C₃₉H₃₈N₆O₁₂
• 分子量: 782.764
• InChiKey: CZSLCZIYYFFGHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.65
• 重原子数：
  57.0
• 可旋转键数：
  20.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  226.96
• 氢给体数：
  1.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctan-1-ol 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以84%的产率得到2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite
  参考文献：
  名称：

  The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups

  摘要：

  The synthesis of non-nucleoside-based phosphoramidites that bear the 2,4-dinitrophenyl group is reported. These labelled phosphoramidites, which have been used in solid-phase oligonucleotide synthesis to attach single and multiple dinitrophenyl groups to the 5'-end of oligonucleotides, are entirely compatible with the normal oligonucleotide synthesis cycle. Multiple labelling can be performed readily in high yield and the resulting oligonucleotides can be purified readily by reversed-phase h.p.l.c. The labelled oligonucleotides have been detected using monoclonal and polyclonal anti-dinitrophenyl antibodies.

  DOI：

  10.1016/0008-6215(92)84170-w
• 作为产物：
  描述：

  2,4-二硝基氟苯 在 吡啶 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctan-1-ol
  参考文献：
  名称：

  The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups

  摘要：

  The synthesis of non-nucleoside-based phosphoramidites that bear the 2,4-dinitrophenyl group is reported. These labelled phosphoramidites, which have been used in solid-phase oligonucleotide synthesis to attach single and multiple dinitrophenyl groups to the 5'-end of oligonucleotides, are entirely compatible with the normal oligonucleotide synthesis cycle. Multiple labelling can be performed readily in high yield and the resulting oligonucleotides can be purified readily by reversed-phase h.p.l.c. The labelled oligonucleotides have been detected using monoclonal and polyclonal anti-dinitrophenyl antibodies.

  DOI：

  10.1016/0008-6215(92)84170-w