4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(2-(1-ethylpiperidin-4-yl)phenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine | 1401436-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(2-(1-ethylpiperidin-4-yl)phenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
• 英文别名: 4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[1-[2-(1-ethylpiperidin-4-yl)phenyl]-2-methylpropan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine
• CAS: 1401436-97-2
• 化学式: C₃₂H₄₀F₂N₈O
• 分子量: 590.719
• InChiKey: OMPYDTIQSINPLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  tert-butyl 4-(2-(2-((4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)amino)-2-methylpropyl)phenyl)piperidine-1-carboxylate 在 sodium cyanoborohydride 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 3.0h， 生成 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(2-(1-ethylpiperidin-4-yl)phenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine
  参考文献：
  名称：

  (ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

  摘要：

  本文提供了（α-取代的芳基氨基或杂环芳基氨基）嘧啶基和1,3,5-三嗪基苯并咪唑类化合物，例如，式I的化合物，以及它们的药物组合物、制备方法，以及作为治疗增殖性疾病的药剂或药物的用途。

  公开号：

  US20120252802A1

文献信息

• (Alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
  申请人：MEI Pharma, Inc.

  公开号：US10064868B2

  公开（公告）日：2018-09-04

  Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.

  本文提供了（α-取代芳烷基氨基或杂芳基烷基氨基）嘧啶基和 1，3，5-三嗪基苯并咪唑，例如，式 I 的化合物，以及它们的药物组合物、制备和作为治疗增殖性疾病的制剂或药物的用途。
• Combination therapy
  申请人：MEI Pharma, Inc.

  公开号：US11351176B2

  公开（公告）日：2022-06-07

  Provided herein are methods of treating diseases, such as cancer, using a combination therapy. In certain embodiments, the methods comprise administering an effective amount of a phosphoinositide-3-kinase (PI3K) inhibitor and an effective amount of a CD20 inhibitor to a patient.

  本文提供了使用联合疗法治疗疾病（如癌症）的方法。在某些实施方案中，这些方法包括向患者施用有效量的磷酸肌醇-3-激酶（PI3K）抑制剂和有效量的 CD20 抑制剂。
• (ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THESE COMPOUNDS FOR USE IN TREATING PROLIFERATIVE DISEASES
  申请人：MEI Pharma, Inc.

  公开号：EP2691384B1

  公开（公告）日：2016-10-26
• COMBINATION THERAPY
  申请人：MEI Pharma, Inc.

  公开号：US20190201409A1

  公开（公告）日：2019-07-04

  Provided herein are methods of treating diseases, such as cancer, using a combination therapy. In certain embodiments, the methods comprise administering an effective amount of a phosphoinositide-3-kinase (PI3K) inhibitor and an effective amount of a second agent selected from a Bruton tyrosine kinase (BTK) inhibitor, a Bcl-2 inhibitor, an EZH2 inhibitor and a combination thereof to a patient.
• TREATMENT OF RELAPSED FOLLICULAR LYMPHOMA
  申请人：MEI Pharma, Inc.

  公开号：US20210196725A1

  公开（公告）日：2021-07-01

  Provided herein are methods treating follicular lymphoma (FL) in subjects having early disease progression after immunochemotherapy using a phosphoinositide-3-kinase (PI3K) inhibitor. In certain embodiments, the methods comprise treating FL in subjects having disease progression within 24 months of initiating first-line or subsequent immunochemotherapy using a phosphoinositide-3-kinase (PI3K) inhibitor.