Pentafluorophenyl pentafluorobenzoate | 14533-82-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Pentafluorophenyl pentafluorobenzoate
• 英文别名: Pentafluorphenyl-pentafluorbenzoat；Pentafluorbenzoesaeurepentafluorphenylester；Pentafluor-benzoesaeure-；Pentafluorobenzoic acid, pentafluorophenyl ester；(2,3,4,5,6-pentafluorophenyl) 2,3,4,5,6-pentafluorobenzoate
• CAS: 14533-82-5
• 化学式: C₁₃F₁₀O₂
• 分子量: 378.126
• InChiKey: ZTQHONLMYPIEDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2,3,4,5,6-五氟苯甲酸 在 吡啶 、 氯化亚砜 作用下， 生成 Pentafluorophenyl pentafluorobenzoate
  参考文献：
  名称：

  Generation, reactions, direct observation, and kinetics of decafluorodiphenylcarbene

  摘要：

  Bis(pentafluorophenyl)diazomethane (1a) was prepared, and reactivities of perfluorodiphenylcarbene (2a) generated by photolysis of la were investigated not only in terms of product analysis but also by using matrix isolation spectroscopy as well as laser flash photolysis techniques. Product distributions observed in the reactions of 2a in benzene, cyclohexane, and trans-1,2-dichloroethylene suggested that 2a reacted with those substrates with moderate reactivities toward carbene mostly in its singlet state presumably owing to the increased electrophilicity induced by fluorine substituents while the reaction with the alkane C-H bonds in concerted fashion was retarded partly due to steric effect in the singlet state which thus decayed to the triplet states that underwent predominantly H atom abstraction forming tetraarylethane. Photolysis of 1a in Ar matrix at 10 K produced 2a which was observed by IR and UV and shown to react with doped O2 to produce ultimately perfluorobenzoate by way of the carbonyl oxide and dioxirane, both intermediates being characterized by IR and UV/vis spectroscopy. Laser flash photolysis of 1a in acetonitrile solution produced a transient absorption (lambda = 320 nm) due to bis(pentafluorophenyl)methyl radical (14a) obviously produced by H atom abstraction of the triplet 2a, which was trapped by oxygen to generate the carbonyl oxide (11a) showing its absorption maximum at 400 nm (tau = 5 ms) and also by 1,4-cyclohexadiene to form the methyl radical (14a) with the rate constant of 1.1 x 10(7) M-1 s-1. The lifetime of the triplet 2a was estimated to be approximately 1 us.

  DOI：

  10.1021/jo00077a040

文献信息

• POLYFLUORINATED AROMATIC ESTERS PREPARATION AND CARBONYL STRETCHING FREQUENCIES
  作者：Robert Filler、James F. White、Andrew J. Kacmarek、Irvine J. Solomon

  DOI：10.1139/v66-353

  日期：1966.10.1

  not available

  不可用
• Tomioka Hideo, Mizutani Kenzoh, Matsumoto Kenji, Hirai Katauyuki, J. Org. Chem, 58 (1993) N 25, S 7128-7134
  作者：Tomioka Hideo, Mizutani Kenzoh, Matsumoto Kenji, Hirai Katauyuki

  DOI：——

  日期：——
• PATHOGEN BINDING AGENTS CONJUGATED TO RADIOISOTOPES AND USES IN IMAGING AND THERAPEUTIC APPLICATIONS
  申请人：Emory University

  公开号：EP3010549A1

  公开（公告）日：2016-04-27
• Pathogen Binding Agents Conjugated to Radioisotopes and Uses in Imaging and Therapeutic Applications
  申请人：EMORY UNIVERSITY

  公开号：US20160130328A1

  公开（公告）日：2016-05-12

  This disclosure relates to binding agents specific for the envelope protein of a virus, e.g., lentivirus, wherein the binding agent is conjugated to a molecule with a radioisotope or positron-emitting radionuclide. In certain embodiments, the disclosure relates to methods of imaging a virus or other pathogen within the body of a subject using binding agents disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing a viral or other pathogenic infection by administering pharmaceutical composition containing radioactive binding agents disclosed herein.
• [EN] PATHOGEN BINDING AGENTS CONJUGATED TO RADIOISOTOPES AND USES IN IMAGING AND THERAPEUTIC APPLICATIONS<br/>[FR] AGENTS DE LIAISON À DES PATHOGÈNES CONJUGUÉS À DES RADIO-ISOTOPES ET LEURS UTILISATIONS DANS DES APPLICATIONS D'IMAGERIE ET THÉRAPEUTIQUES
  申请人：UNIV EMORY

  公开号：WO2014204800A1

  公开（公告）日：2014-12-24

  This disclosure relates to binding agents specific for the envelope protein of a virus, e.g., lentivirus, wherein the binding agent is conjugated to a molecule with a radioisotope or positron-emitting radionuclide. In certain embodiments, the disclosure relates to methods of imaging a virus or other pathogen within the body of a subject using binding agents disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing a viral or other pathogenic infection by administering pharmaceutical composition containing radioactive binding agents disclosed herein.