(1R,2R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile | 1205676-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1R,2R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
• CAS: 1205676-36-3
• 化学式: C₈H₁₂N₂
• 分子量: 136.197
• InChiKey: ZLISHYOBWCRHFE-ACZMJKKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  sodium cyanide 、 (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-sulfonate 以 水 为溶剂， 反应 3.5h， 生成 (1R,2R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile 、 (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile
  参考文献：
  名称：

  [EN] BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
  [FR] PROCÉDÉS BIOCATALYTIQUES POUR LA PRÉPARATION DE COMPOSÉS DE PROLINE BICYCLIQUES CONDENSÉS SENSIBLEMENT PURS SUR LE PLAN STÉRÉO-ISOMÉRIQUE

  摘要：

  公开号：

  WO2010008828A3

文献信息

• BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
  申请人：Mijts Benjamin

  公开号：US20100063300A1

  公开（公告）日：2010-03-11

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本披露提供了下列结构式的基本对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供了用于它们制备的生物催化过程以及在这些过程中使用的酶。
• Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds
  申请人：Mijts Benjamin

  公开号：US20120244581A1

  公开（公告）日：2012-09-27

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本公开提供了下列结构式的大体对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供了其生物催化制备的方法，以及用于这些过程中所使用的酶。
• Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir
  申请人：Lalonde James

  公开号：US20120289709A1

  公开（公告）日：2012-11-15

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本公开提供以下结构式的基本对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供其生物催化制备的过程，以及用于该过程的酶。
• Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors
  申请人：Mijts Benjamin

  公开号：US20120130087A1

  公开（公告）日：2012-05-24

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本公开提供以下结构式的基本对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供其生物催化制备的过程，以及用于这些过程中使用的酶。
• Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2481737A1

  公开（公告）日：2012-08-01

  The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本公开提供了本文所述的结构式 II 至 VII 的基本立体纯的融合双环脯氨酸化合物，以及制备这些化合物的生物催化工艺和用于这些工艺的酶。