lactic acid 2,2,6,6-tetramethyl-4-piperidyl ester | 216692-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: lactic acid 2,2,6,6-tetramethyl-4-piperidyl ester
• 英文别名: (2,2,6,6-tetramethylpiperidin-4-yl) 2-hydroxypropanoate
• CAS: 216692-32-9
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: HWQGURLYBGAEPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lactic acid 2,2,6,6-tetramethyl-4-piperidyl ester 、 2,2,6-三甲基-4H-1,3-二英-4-酮 以 甲苯 为溶剂， 反应 3.0h， 生成 2-(acetoacetyloxy)-propionic acid 2,2,6,6-tetramethyl-4-piperidyl ester
  参考文献：
  名称：

  &bgr;-ketoesters for use as polymer stabilizers

  摘要：

  -Keto酯及其从醇类或多元醇类中得到的烯胺适用于稳定聚合物，其化学式为：A[(O—CHR4—Z—CHR5)m—O—CO—CHR1—CO—R3]n和A[(O—CHR4—Z—CHR5)m—O—CO—CR1═C(—NHR2)—R3]n，其中：A是从羟基烷酸酯、糖及其糖苷、糖醇、糖酸及其酯、寡糖中选择的醇或多元醇的残基；m是从0到6的整数；n是从1到多元醇中羟基总数的数字；R1是氢、C1-C8烷基、C3-C8烯基或环烷基（烷基）或C6-C8芳基或芳基烷基；R2是氢、C1-C6烷基、C2-C6羟基烷基或C3-C6烯基；R3是C1-C18烷基、烷氧基或烷基氨基、C3-C18烯基、烷酰甲基、烷氧羰基甲基或环烷基（烷基）、C6-C18芳基、芳氧基、芳基氨基、芳基烷基、芳基烷氧基或芳基烷基氨基，或C8-C18芳酰甲基、芳氧羰基甲基或芳基碳酰胺甲基；R4和R5独立地是氢或甲基；Z是直接键、CH2、CHOH、CH—O—CO—CHR1—CO—R3或O—CO—CR1═C(—NHR2)—R3。

  公开号：

  US06355713B1

文献信息

• B-ketoesters for use as polymer stabilisers
  申请人：AKCROS CHEMICALS

  公开号：EP0881253A1

  公开（公告）日：1998-12-02

  β-Ketoesters derived from alcohols or polyols, which are natural product or can be obtained from natural products by fermentation processes and optional subsequent oxidation or reduction, are suitable for stabilising polymers, The ketoesters are represented by formula 1:         A[(O-CHR4-Z-CHR5)m-O-CO-CR1R2-CO-R3]n wherein: Ais the residue of an alcohol or polyol selected from hydroxyalkanoic acid esters, sugars and their glycosides, sugar alcohols, sugar acids and their esters, and oligosaccharides; mis an integer number from 0 up to 6; nis a number from 1 up to the total number of hydroxyl groups in the polyol; R1is hydrogen, C1-C8 alkyl, C3-C8 alkenyl or cycloalkyl(alkyl) or C6-C8 aryl or aralkyl; R2is hydrogen, C1-C8 alkyl or C3-C8 alkenyl; R3is C1-C18 alkyl, alkoxy or alkylamino, C3-C18 alkenyl, alkanoylmethyl, alkoxycarbonylmethyl or cycloalkyl(alkyl), C6-C18 aryl, aryloxy, arylamino, aralkyl, aralkoxy or aralkylamino, or C8-C18 aroylmethyl, aryloxycarbonylmethyl or arylcarbamoylmethyl; R4 and R5are independently hydrogen or methyl; and Zis a direct bond, CH2, CHOH or CH-O-CO-CR1R2-CO-R3.

  来源于醇或多元醇的β-酮酸酯是天然产物，或者可以通过发酵过程和可选的氧化或还原获得，适用于稳定聚合物。酮酸酯由公式1表示： A[(O-CHR4-Z-CHR5)m-O-CO-CR1R2-CO-R3]n，其中： A是从羟基烷酸酯，糖及其糖苷，糖醇，糖酸及其酯，寡糖中选择的醇或多元醇的残留物; m是从0到6的整数; n是从1到多元醇中羟基总数的数字; R1是氢，C1-C8烷基，C3-C8烯基或环烷基（烷基）或C6-C8芳基或芳基烷基; R2是氢，C1-C8烷基或C3-C8烯基; R3是C1-C18烷基，烷氧基或烷基氨基，C3-C18烯基，烷酰甲基，烷氧羰基甲基或环烷基（烷基），C6-C18芳基，芳氧基，芳基氨基，芳基烷基，芳基烷氧基或芳基烷基氨基，或C8-C18芳香基甲基，芳氧羰基甲基或芳基氨基甲基; R4和R5独立地是氢或甲基; Z是直接键，CH2，CHOH或CH-O-CO-CR1R2-CO-R3。
• [EN] beta -KETOESTERS FOR USE AS POLYMER STABILISERS<br/>[FR] beta -CETOESTERS UTILISES EN TANT QUE STABILISANTS DE POLYMERES
  申请人：AKCROS CHEMICALS

  公开号：WO1998054246A1

  公开（公告）日：1998-12-03

  (EN) $g(b)-Ketoesters and their enamines derived from alcohols or polyols, especially sugar alcohols and their anhydro derivatives, which are natural products or can be obtained from natural products by fermentation processes and optional subsequent oxidation or reduction, are suitable for stabilising polymers. The ketoesters and enamines are represented by formulae (1) and (2) respectively: A[(O-CHR4-Z-CHR5)m-O-CO-CHR1-CO-R3]n and A[(O-CHR4-Z-CHR5)m-O-CO-CR1=C(-NHR2)-R3]n, wherein: A is the residue of an alcohol or polyol selected from hydroxyalkanoic acid esters, sugars and their glycosides, sugar alcohols, sugar acids and their esters, and oligosaccharides; m is an integer number from 0 up to 6; n is a number from 1 up to the total number of hydroxyl groups in the polyol; R1 is hydrogen, C1-C8 alkyl, C3-C8 alkenyl or cycloalkyl(alkyl) or C6-C8 aryl or aralkyl; R2 is hydrogen, C1-C6 alkyl, C2-C6 hydroxyalkyl or C3-C6 alkenyl; R3 is C1-C18 alkyl, alkoxy or alkylamino, C3-C18 alkenyl, alkanoylmethyl, alkoxycarbonylmethyl or cycloalkyl(alkyl), C6-C18 aryl, aryloxy, arylamino, aralkyl, aralkoxy or aralkylamino, or C8-C18 aroylmethyl, aryloxycarbonylmethyl or arylcarbamoylmethyl; R4 and R5 are independently hydrogen or methyl; and Z is a direct bond, CH2, CHOH, CH-O-CO-CHR1-CO-R3 or O-CO-CR1=C(-NHR2)-R3.(FR) Cette invention se rapporte à des $g(b)-cétoesters, et à leurs énamines, dérivés d'alcools ou polyols, notamment d'itols et de leurs dérivés anhydro. Ces $g(b)-cétoesters sont des produits naturels ou sont dérivés de produits naturels par des processus de fermentation suivis éventuellement d'une oxydation ou d'une réduction, et ils s'avèrent utiles à la stabilisation des polymères. Ces cétoesters et énamines sont représentés respectivement par les formules (1) et (2) suivantes: A[O-CHR4-Z-CHR5)m-O-CO-CHR1-CO-R3]n et A[(O-CHR4-Z-CHR5)m-O-CO-CR1=C(-NHR2)-R3]n, dans lesquelles A est le reste d'un alcool ou d'un polyol sélectionné parmi des esters d'acide hydroxyalcanoïque, des sucres et leurs glycosides, des itols, des acides glucidiques et leurs esters et des oligosaccharides; m est un entier compris entre 0 et 6; n est un nombre compris entre 1 et le nombre total de groupes hydroxyle du polyol; R1 est hydrogène, alkyle C1-C8, alkényle C3-C8 ou cycloalkyl(alkyle) ou aryle C6-C8 ou aralkyle; R2 est hydrogène, alkyle C1-C6, hydroxyalkyle C2-C6 ou alkényle C3-C6; R3 est alkyle C1-C18, alcoxy ou alkylamino, alkényle C3-C18, alcanoylméthyle, alcoxycarbonylméthyle ou cycloalkyl(alkyle), C6-C18 aryle, aryloxy, arylamino, aralkyle, aralcoxy ou aralkylamino ou C8-C18 aroylméthyle, aryloxycarbonylméthyle ou arylcarbamoylméthyle; R4 et R5 sont indépendamment hydrogène ou méthyle; et Z est une liaison directe, CH2, CHOH, CH-O-CO-CHR1-CO-R3 ou O-CO-CR1=C(-NHR2)-R3.

  该发明涉及酮酯及其来自醇或非醇的羰基腙，特别是例如糖醇及其无羟基衍生物的有关结构体。这些酮酯和羰基腙是以式(1)和式(2)所表示的结构形式存在的。在这些结构中，A是一个代表从水溶性醇酸酯、葡萄糖和其糖苷、糖醇、糖酸及其酯化物和寡糖中得到的官能团的残基的部分；m是0到6范围内的一个整数；n是与多醇中的羟基总数相对应的1到总值； R1是氢、C1-C8的烷基、C3-C8的烯基或环烷基(烷基)、C6-C8的aryl或aralkyl的结构；R2是氢、C1-C6的烷基、C2-C6的羟基烷基或者C3-C6的烯基的结构；R3是C1-C18的烷基、羟基或氨基烷基、C3-C18的烯基、C6-C18的羰基甲烷、羰基甲氧基或羰基羰基甲苯、C6-C18的aryl或同样单元化的衍生物结构；R4和R5是独立的氢或甲基；Z是一个直接键、CH2、CH-O-CO-CHR1-CO-R3，或者O-CO-CR1=C(-NHR2)-R3的结构。
• BETA-KETOESTERS FOR USE AS POLYMER STABILISERS
  申请人：AKCROS CHEMICALS

  公开号：EP0986605A1

  公开（公告）日：2000-03-22
• US6355713B1
  申请人：——

  公开号：US6355713B1

  公开（公告）日：2002-03-12
• &bgr;-ketoesters for use as polymer stabilizers
  申请人：Akcros, Chemicals

  公开号：US06355713B1

  公开（公告）日：2002-03-12

  &bgr;-Ketoesters and their enamines derived from alcohols or polyols are suitable for stabilizing polymers, and are represented by formulae: A[(O—CHR4—Z—CHR5)m—O—CO—CHR1—CO—R3]n and A[(O—CHR4—Z—CHR5)m—O—CO—CR1═C(—NHR2)—R3]n, wherein: A is the residue of an alcohol or polyol selected from hydroxyalkanoic acid esters, sugars and their glycosides, sugar alcohols, sugar acids and their esters, and oligosaccharides; m is an integer number from 0 up to 6; n is a number from 1 up to the total number of hydroxyl groups in the polyol; R1 is hydrogen, C1-C8 alkyl, C3-C8 alkenyl or cycloalkyl (alkyl) or C6-C8 aryl or aralkyl; R2 is hydrogen, C1-C6 alkyl, C2-C6 hydroxyalkyl or C3-C6 alkenyl; R3 is C1-C18 alkyl, alkoxy or alkylamino, C3-C18 alkenyl, alkanoylmethyl, alkoxycarbonylmethyl or cycloalkyl(alkyl), C6-C18 aryl, aryloxy, arylamino, aralkyl, aralkoxy or aralkylamino, or C8-C18 aroylmethyl, aryloxycarbonylmethyl or arylcarbamoylmethyl; R4 and R5 are independently hydrogen or methyl; and Z is a direct bond, CH2, CHOH, CH—O—CO—CHR1—CO—R3 or O—CO—CR1═C(—NHR2)—R3.

  -Keto酯及其从醇类或多元醇类中得到的烯胺适用于稳定聚合物，其化学式为：A[(O—CHR4—Z—CHR5)m—O—CO—CHR1—CO—R3]n和A[(O—CHR4—Z—CHR5)m—O—CO—CR1═C(—NHR2)—R3]n，其中：A是从羟基烷酸酯、糖及其糖苷、糖醇、糖酸及其酯、寡糖中选择的醇或多元醇的残基；m是从0到6的整数；n是从1到多元醇中羟基总数的数字；R1是氢、C1-C8烷基、C3-C8烯基或环烷基（烷基）或C6-C8芳基或芳基烷基；R2是氢、C1-C6烷基、C2-C6羟基烷基或C3-C6烯基；R3是C1-C18烷基、烷氧基或烷基氨基、C3-C18烯基、烷酰甲基、烷氧羰基甲基或环烷基（烷基）、C6-C18芳基、芳氧基、芳基氨基、芳基烷基、芳基烷氧基或芳基烷基氨基，或C8-C18芳酰甲基、芳氧羰基甲基或芳基碳酰胺甲基；R4和R5独立地是氢或甲基；Z是直接键、CH2、CHOH、CH—O—CO—CHR1—CO—R3或O—CO—CR1═C(—NHR2)—R3。