bis(hydroxymethyl)phosphinic acid methyl ester | 67309-03-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦酸及其衍生物
• 英文名称: bis(hydroxymethyl)phosphinic acid methyl ester
• 英文别名: bis(hydroxymethyl)phosphinic acid O-methyl ester；Methyl bis(hydroxymethyl)phosphinate；O-methyl bis(hydroxymethyl)phosphinate；[hydroxymethyl(methoxy)phosphoryl]methanol
• CAS: 67309-03-9
• 化学式: C₃H₉O₄P
• 分子量: 140.076
• InChiKey: NCAKDDLCFZOMKI-UHFFFAOYSA-N

物化性质

• 沸点：
  252.6±50.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(hydroxymethyl)phosphinic acid methyl ester 、 N6,N6,O2',O3'-tetrabenzoyladenosine 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 ammonium hydroxide 作用下， 生成 bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxido-sulfidophosphaniumyl]oxymethyl]phosphinate
  参考文献：
  名称：

  Diadenylated polyols as new non-isopolar analogues of diadenosine tri- and tetraphosphates

  摘要：

  A series of diadenosine polyphosphate-mimics were prepared based upon phosphorothioylation of the hydroxyl functions of polyols 1 and 1,3,2-oxathiaphospholane ring-opening condensation methodology. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01802-x
• 作为产物：
  描述：

  二(羟基甲基)次磷酸 、 三甲基硅烷化重氮甲烷 在 溶剂黄146 作用下， 以 甲醇 、 正己烷 、 甲苯 为溶剂， 生成 bis(hydroxymethyl)phosphinic acid methyl ester
  参考文献：
  名称：

  Diindolo compounds and pharmaceutical compositions containing them

  摘要：

  本发明涉及以下式子的化合物：##STR1## 其中X，Y，Z，R.sub.1，R.sub.2，R.sub.4和R.sub.5如此处所述。这些化合物可用作治疗炎症，肿瘤和牛皮癣的药物。

  公开号：

  US05589472A1

文献信息

• Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues
  作者：Bogdan Walkowiak、Janina Baraniak、Czeslaw S. Cierniewski、Wojciech Stec

  DOI：10.1016/s0960-894x(02)00318-9

  日期：2002.8

  The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.

  报道了新的二磷酸腺苷多磷酸酯类似物对血小板聚集的合成和生物学评价。最具活性的是具有硫原子的磷取代了双（羟甲基）次膦酸的腺苷残基和羟甲基上的一个或两个非桥接氧。
• Bis(hydroxymethyl)phosphinic acid analogues of acyclic nucleosides; synthesis and incorporation into short DNA oligomers
  作者：B Nawrot、O Michalak、M Nowak、A Okruszek、M Dera、W.J Stec

  DOI：10.1016/s0040-4039(02)01067-5

  日期：2002.7

  nucleosides based on a bis(hydroxymethyl)phosphinic acid (BHPA) backbone were obtained by condensation of the bis(4,4′-dimethoxytrityl) derivative of BHPA with N-1- or N-3-(2-hydroxyethyl)thymine in the presence of MSNT, or by an Appel reaction with N-1- or N-3-(2-aminoethyl)thymine. After selective deprotection and phosphitylation they were used as monomers for automated solid support synthesis of short oligomers

  通过将BHPA的双（4,4'-二甲氧基三苯甲基）衍生物与N -1-或N -3-（2-羟乙基）缩合获得基于双（羟甲基）次膦酸（BHPA）骨架的无环核苷的新类似物。胸腺嘧啶在MSNT的存在下，或与N -1-或N -3-（2-氨基乙基）胸腺嘧啶的Appel反应。选择性脱保护和磷酸化后，它们被用作亚磷酰胺方法自动合成短寡聚物的固体支持物的单体。
• Romanenko,V.D. et al., Journal of general chemistry of the USSR, 1978, vol. 48, # 5, p. 1082 - 1083
  作者：Romanenko,V.D. et al.

  DOI：——

  日期：——
• Diadenylated polyols as new non-isopolar analogues of diadenosine tri- and tetraphosphates
  作者：Janina Baraniak、Ewa Wasilewska、Dariusz Korczyński、Wojciech J. Stec

  DOI：10.1016/s0040-4039(99)01802-x

  日期：1999.12

  A series of diadenosine polyphosphate-mimics were prepared based upon phosphorothioylation of the hydroxyl functions of polyols 1 and 1,3,2-oxathiaphospholane ring-opening condensation methodology. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Diindolo compounds and pharmaceutical compositions containing them
  申请人：——

  公开号：US05589472A1

  公开（公告）日：1996-12-31

  The invention relates to compounds of the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2, R.sub.4, and R.sub.5, are as described herein. These compounds are useful as agents for the treatment of inflammation, tumors and psoriasis.

  本发明涉及以下式子的化合物：##STR1## 其中X，Y，Z，R.sub.1，R.sub.2，R.sub.4和R.sub.5如此处所述。这些化合物可用作治疗炎症，肿瘤和牛皮癣的药物。