(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-methanone | 1505455-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: (8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-methanone
• 英文别名: (8-oxa-3-azabicyclo[3.2.1]octan-3-yl)methanone；8-Oxa-3-azabicyclo[3.2.1]octane-3-carbaldehyde
• CAS: 1505455-71-9
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: ZYIFIOXQMZMTAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-氧杂-3-氮杂双环[3,2,1]辛烷 、 二氧化碳 在 palladium/alumina 、 氢气 作用下， 以 正辛烷 为溶剂， 130.0 ℃ 、3.0 MPa 条件下， 反应 24.0h， 以83%的产率得到(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-methanone
  参考文献：
  名称：

  通过简单而有效的非均相钯催化剂催化通过二氧化碳再循环的胺甲酰化反应。

  摘要：

  一种简单有效的Pd / Al2O3-NR-RD催化剂，是通过两步过程将钯沉积在形状可控的Al2O3-NR载体上而制备的，该过程涉及水热合成Al2O3-NRs，然后进行钯的还原沉积。该催化剂在温和条件下通过CO2-H2催化胺的甲酰化反应具有很高的活性，收率高达96％。

  DOI：

  10.1039/c3cc46427j

文献信息

• USE OF QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Jung Birgit

  公开号：US20110281860A1

  公开（公告）日：2011-11-17

  The present invention relates to the use of quinazoline derivatives, which show EGFR inhibitory activity, for the prevention and/or treatment of virus-induced diseases, preferably virus induced respiratory diseases and exacerbation in chronic airway diseases such as COPD or asthma.

  本发明涉及使用具有EGFR抑制活性的喹唑啉衍生物，用于预防和/或治疗病毒引起的疾病，优选是病毒引起的呼吸道疾病以及慢性气道疾病（如COPD或哮喘）的恶化。
• Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
  申请人：Himmelsbach Frank

  公开号：US20050070560A1

  公开（公告）日：2005-03-31

  Compounds of the formula having an inhibitory action on the signal transduction mediated by tyrosine kinases, and being useful for the treatment of oncoses and of benign prostate hyperplasia (BPH), of diseases of the lung and of the airways. Exemplary compounds are: (R)-4-(1-Phenylethylamino)-6-[1-(tert-butyloxycarbonyl)piperidin-4-yloxy]-7-methoxy-quinazoline and (R)-4-(1-Phenylethylamino)-6-(piperidin-4-yloxy)-7-methoxyquinazoline dihydrochloride.

  该化合物的公式具有抑制酪氨酸激酶介导的信号转导作用，并可用于治疗肿瘤和良性前列腺增生症（BPH），肺部和气道疾病。示例化合物包括：（R）-4-（1-苯乙基氨基）-6- [1-（叔丁基氧羰基）哌啶-4-氧基] -7-甲氧基喹噁啉和（R）-4-（1-苯乙基氨基）-6-（哌啶-4-氧基）-7-甲氧基喹噁啉双盐酸盐。
• Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
  申请人：Himmelsbach Frank

  公开号：US20050182043A1

  公开（公告）日：2005-08-18

  The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.

  本发明涉及一种治疗疾病的方法，所述疾病包括良性或恶性肿瘤、呼吸道和肺部疾病、胆道和胆囊疾病以及胃肠道疾病，通过向需要治疗的患者施用以下一般式的双环杂环基的治疗有效量：其中所述取代基如定义所述。
• BICYCLIC HETEROCYCLIC COMPOUNDS PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THE SAME
  申请人：HIMMELSBACH Frank

  公开号：US20110077246A1

  公开（公告）日：2011-03-31

  The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.

  本发明涉及治疗疾病的方法，所述疾病包括良性或恶性肿瘤、呼吸道和肺部疾病、胃肠道疾病、胆管和胆囊疾病，通过向需要治疗的患者施用下列一般式的双环杂环基的治疗有效量：其中所述取代基如本文所定义。
• 4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1492536B1

  公开（公告）日：2012-05-09