Carbonic acid 6-{3-[3-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynylcarbamoyl]-propionylamino}-hexyl ester 9H-fluoren-9-ylmethyl ester | 339569-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Carbonic acid 6-{3-[3-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynylcarbamoyl]-propionylamino}-hexyl ester 9H-fluoren-9-ylmethyl ester
• 英文别名: 6-[[4-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-ynylamino]-4-oxobutanoyl]amino]hexyl 9H-fluoren-9-ylmethyl carbonate
• CAS: 339569-44-7
• 化学式: C₅₈H₆₀N₄O₁₂
• 分子量: 1005.13
• InChiKey: SPRXFHJIKOIIPQ-SXWJAJOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  74
• 可旋转键数：
  25
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  200
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 Carbonic acid 6-{3-[3-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynylcarbamoyl]-propionylamino}-hexyl ester 9H-fluoren-9-ylmethyl ester 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到6-[[4-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-ynylamino]-4-oxobutanoyl]amino]hexyl 9H-fluoren-9-ylmethyl carbonate
  参考文献：
  名称：

  Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides

  摘要：

  The efficient incorporation of reporter groups into oligonucleotides at specific sites has been facilitated by the synthesis of a novel modified thymidine monomer with an FMOC-protected hydroxyl group on a linker. The primary hydroxyl group can be deprotected during or after solid-phase oligonucleotide synthesis and reacted with any reporter phosphoramidite. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00224-6
• 作为产物：
  描述：

  9H-fluoren-9-ylmethyl 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexyl carbonate 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 吡啶 、 二氯甲烷 、 三氟乙酸 为溶剂， 生成 Carbonic acid 6-{3-[3-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynylcarbamoyl]-propionylamino}-hexyl ester 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides

  摘要：

  The efficient incorporation of reporter groups into oligonucleotides at specific sites has been facilitated by the synthesis of a novel modified thymidine monomer with an FMOC-protected hydroxyl group on a linker. The primary hydroxyl group can be deprotected during or after solid-phase oligonucleotide synthesis and reacted with any reporter phosphoramidite. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00224-6