1-((S)-2-Azido-3-trityloxy-propoxy)-4-methoxy-benzene | 221697-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-((S)-2-Azido-3-trityloxy-propoxy)-4-methoxy-benzene
• CAS: 221697-41-2
• 化学式: C₂₉H₂₇N₃O₃
• 分子量: 465.552
• InChiKey: KFVPQBGMUQXNLP-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.76
• 重原子数：
  35.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  76.45
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-((S)-2-Azido-3-trityloxy-propoxy)-4-methoxy-benzene 在 四氮唑 、 Amberlyst-R₁₅ (H+) 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 Phosphorous acid (S)-2-azido-3-(4-methoxy-phenoxy)-propyl ester 2-cyano-ethyl ester (2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-(4-nitro-phenoxy)-tetrahydro-pyran-2-ylmethyl ester
  参考文献：
  名称：

  Synthesis and absolute configuration of a novel aminoglycoglycerolipid, species-specific major immunodeterminant of Mycoplasma fermentans

  摘要：

  In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their H-1-H-1-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00191-4
• 作为产物：
  描述：

  三苯甲基-(R)-缩水甘油醚 在 吡啶 、 sodium azide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-((S)-2-Azido-3-trityloxy-propoxy)-4-methoxy-benzene
  参考文献：
  名称：

  Synthesis and absolute configuration of a novel aminoglycoglycerolipid, species-specific major immunodeterminant of Mycoplasma fermentans

  摘要：

  In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their H-1-H-1-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00191-4