(4-dimethylaminophenyl)-(2,2-dimethyl-2H-thiochromen-4-yl)methanol | 1072933-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: (4-dimethylaminophenyl)-(2,2-dimethyl-2H-thiochromen-4-yl)methanol
• CAS: 1072933-00-6
• 化学式: C₂₀H₂₃NOS
• 分子量: 325.475
• InChiKey: JCELXKHEONYRAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.75
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  23.47
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (4-dimethylaminophenyl)-(2,2-dimethyl-2H-thiochromen-4-yl)methanol 在 三溴化磷 作用下， 以 苯 为溶剂， 以59%的产率得到dimethyl-[4-(3-methyl-2-methylene-2H-thiochromen-4-ylmethyl)phenyl]amine
  参考文献：
  名称：

  An unexpected reaction of phosphorous tribromide on chromanone, thiochromanone, 3,4-dihydro-2H-benzo[b]thiepin-5-one, 3,4-dihydro-2H-benzo[b]oxepin-5-one and tetralone derived allylic alcohols: a case study

  摘要：

  Treatment of chromanone, thiochromanone, tetralone and benzo[b]thiepinone derived allylic alcohols with phosphorous tribromide furnished unexpected products instead of desired bromo derivatives. Reaction of 7-methoxy-2,2-dimethylchromenyl-aryl-methanols and 7-methoxy-2,2-dimethylthio-chromenyl-aryl-methanols with PBr3 gave saturated carbonyls and exocyclic olefins depending on the substituents at R-4, whereas allylic alcohols without 7-methoxy substituent furnished rearranged products. Several related analogs varying in ring size, heteroatom in the ring and substituents at various positions were synthesized and studied. Reactions of other phosphorous-based reagents like PPh3, PPh3/I-2 and PPh3Br2 on allylic alcohols were also attempted. A case study is presented here. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.106
• 作为产物：
  描述：

  对二甲氨基苯甲醛 、 4-bromo-2,2-dimethyl-2H-thiochromene 在 正丁基锂 作用下， 以51%的产率得到(4-dimethylaminophenyl)-(2,2-dimethyl-2H-thiochromen-4-yl)methanol
  参考文献：
  名称：

  An unexpected reaction of phosphorous tribromide on chromanone, thiochromanone, 3,4-dihydro-2H-benzo[b]thiepin-5-one, 3,4-dihydro-2H-benzo[b]oxepin-5-one and tetralone derived allylic alcohols: a case study

  摘要：

  Treatment of chromanone, thiochromanone, tetralone and benzo[b]thiepinone derived allylic alcohols with phosphorous tribromide furnished unexpected products instead of desired bromo derivatives. Reaction of 7-methoxy-2,2-dimethylchromenyl-aryl-methanols and 7-methoxy-2,2-dimethylthio-chromenyl-aryl-methanols with PBr3 gave saturated carbonyls and exocyclic olefins depending on the substituents at R-4, whereas allylic alcohols without 7-methoxy substituent furnished rearranged products. Several related analogs varying in ring size, heteroatom in the ring and substituents at various positions were synthesized and studied. Reactions of other phosphorous-based reagents like PPh3, PPh3/I-2 and PPh3Br2 on allylic alcohols were also attempted. A case study is presented here. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.106