5-pentadecyl-2-((piperidin-1-yl)methyl)phenol | 1425050-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-pentadecyl-2-((piperidin-1-yl)methyl)phenol
• 英文别名: 5-Pentadecyl-2-(piperidin-1-ylmethyl)phenol；5-pentadecyl-2-(piperidin-1-ylmethyl)phenol
• CAS: 1425050-09-4
• 化学式: C₂₇H₄₇NO
• 分子量: 401.676
• InChiKey: GBTSTSWFWBSFCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌啶 、 聚合甲醛 、 3-十五烷基苯酚 生成 5-pentadecyl-2-((piperidin-1-yl)methyl)phenol
  参考文献：
  名称：

  Interaction of Piperidin Derivative of Mannich Base with DPPC Liposomes

  摘要：

  The long chain Mannich bases, especially with the piperidine and morpholine groups, display very promising antimicrobial activity. In order to extend our knowledge on their impact on biological systems, we examined the interactions of the 5-pentadecyl-2-((piperidin-1-yl)methyl)phenol (PPDP) with model lipid membrane by means of differential scanning calorimetry (DSC) and fluorescence measurements. The small unilamellar vesicles of dipalmitoylophosphatidylcholine (DPPC) with different piperidine Mannich base concentration were investigated as a function of the increase of temperature. The phase separation accompanied by the rise of the transition enthalpy of both subcomponents, the increase of the function of the GP values of Laurdan versus the wavelength of excitation in the gel phase of PPDP/DPPC systems, and no remarkable differences in the fluorescence anisotropy of PPDP molecules in lipid environment for different mixtures of PPDP/DPPC was observed. Additionally, it was shown that PPDP itself interdigitated in solid state.

  DOI：

  10.1021/jp311825h

文献信息

• Interaction of Piperidin Derivative of Mannich Base with DPPC Liposomes
  作者：Katarzyna Cieślik-Boczula、Rafał Michał Petrus、Gottfried Köhler、Tadeusz Lis、Aleksander Koll

  DOI：10.1021/jp311825h

  日期：2013.3.14

  The long chain Mannich bases, especially with the piperidine and morpholine groups, display very promising antimicrobial activity. In order to extend our knowledge on their impact on biological systems, we examined the interactions of the 5-pentadecyl-2-((piperidin-1-yl)methyl)phenol (PPDP) with model lipid membrane by means of differential scanning calorimetry (DSC) and fluorescence measurements. The small unilamellar vesicles of dipalmitoylophosphatidylcholine (DPPC) with different piperidine Mannich base concentration were investigated as a function of the increase of temperature. The phase separation accompanied by the rise of the transition enthalpy of both subcomponents, the increase of the function of the GP values of Laurdan versus the wavelength of excitation in the gel phase of PPDP/DPPC systems, and no remarkable differences in the fluorescence anisotropy of PPDP molecules in lipid environment for different mixtures of PPDP/DPPC was observed. Additionally, it was shown that PPDP itself interdigitated in solid state.