(3S,4R,6R)-6-O-benzyl-3,4-O-cyclohexylidene-1-methylazepane | 1269439-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: (3S,4R,6R)-6-O-benzyl-3,4-O-cyclohexylidene-1-methylazepane
• CAS: 1269439-28-2
• 化学式: C₂₀H₂₉NO₃
• 分子量: 331.455
• InChiKey: MYNMERDIJJJYKW-QRVBRYPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  30.93
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (3S,4R,6R)-6-O-benzyl-3,4-O-cyclohexylidene-1-methylazepane 在 盐酸 、 10% palladium on activated carbon 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 以69%的产率得到(3S,4R,6R)-1-N-methylazepane-3,4,6-triol
  参考文献：
  名称：

  Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors

  摘要：

  An effective synthetic method for polyhydroxylated azepanes that contain an alkyl group (Me or Bu) at either the 7- or N-positions is developed. The synthetic routes are accomplished in eight to ten steps from D-(-)-quinic acid. Among the compounds synthesized, the polyhydroxy 7-butyl azepane (compound 3), which possessed the R-configuration at C-7 position, is shown to give potent inhibition against beta-galactosidase (IC50 = 3 mu M). Preliminary biological data indicate that the length of alkyl groups along with the proper stereochemistry at the C-7 position is essential for acquiring extra binding affinity. Using similar synthetic routes, the polyhydroxy N-methyl and N-butyl azepanes are synthesized for the comparison of their biological activities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.11.014
• 作为产物：
  描述：

  (1R,4S,5R)-1-O-benzyl-4,5-O-cyclohexylidene-1,4,5-trihydroxy-2-cyclohexene 、 甲胺 在 ruthenium trichloride 、 sodium periodate 、 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 10.0h， 以49%的产率得到(3S,4R,6R)-6-O-benzyl-3,4-O-cyclohexylidene-1-methylazepane
  参考文献：
  名称：

  Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors

  摘要：

  An effective synthetic method for polyhydroxylated azepanes that contain an alkyl group (Me or Bu) at either the 7- or N-positions is developed. The synthetic routes are accomplished in eight to ten steps from D-(-)-quinic acid. Among the compounds synthesized, the polyhydroxy 7-butyl azepane (compound 3), which possessed the R-configuration at C-7 position, is shown to give potent inhibition against beta-galactosidase (IC50 = 3 mu M). Preliminary biological data indicate that the length of alkyl groups along with the proper stereochemistry at the C-7 position is essential for acquiring extra binding affinity. Using similar synthetic routes, the polyhydroxy N-methyl and N-butyl azepanes are synthesized for the comparison of their biological activities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.11.014