N-{2-oxo-1-[2'-oxo-2'-(piperidin-1''-yl)-ethyl]-1,2-dihydropyridin-3-yl}benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-{2-oxo-1-[2'-oxo-2'-(piperidin-1''-yl)-ethyl]-1,2-dihydropyridin-3-yl}benzamide
• 英文别名: N-[2-oxo-1-(2-oxo-2-piperidin-1-ylethyl)pyridin-3-yl]benzamide
• 化学式: C₁₉H₂₁N₃O₃
• 分子量: 339.394
• InChiKey: AMNLLAOCODOBIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 ethyl [3-(benzoylamino)-2-oxopyridin-1(2H)-yl]acetate 反应 2.0h， 以92%的产率得到N-{2-oxo-1-[2'-oxo-2'-(piperidin-1''-yl)-ethyl]-1,2-dihydropyridin-3-yl}benzamide
  参考文献：
  名称：

  A facile and efficient method for the synthesis of novel pyridone analogues by aminolysis of an ester under solvent-free conditions

  摘要：

  A series of 15 pure novel N-alkylated pyridone derivatives have been synthesized in 73-96% yields on treatment of ethyl (2-pyridone)acetates with structurally diverse amines in an efficient aminolysis procedure under 'solvent-free' conditions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.09.068

文献信息

• A facile and efficient method for the synthesis of novel pyridone analogues by aminolysis of an ester under solvent-free conditions
  作者：N. David Karis、Wendy A. Loughlin、Ian D. Jenkins

  DOI：10.1016/j.tet.2007.09.068

  日期：2007.12

  A series of 15 pure novel N-alkylated pyridone derivatives have been synthesized in 73-96% yields on treatment of ethyl (2-pyridone)acetates with structurally diverse amines in an efficient aminolysis procedure under 'solvent-free' conditions. (c) 2007 Elsevier Ltd. All rights reserved.