1-(吗啉-4-基甲基)哌啶-2,6-二酮 | 89003-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(吗啉-4-基甲基)哌啶-2,6-二酮
• 英文名称: N-(morpholin-4-ylmethyl)glutarimide
• 英文别名: 1-[(Morpholin-4-yl)methyl]piperidine-2,6-dione；1-(morpholin-4-ylmethyl)piperidine-2,6-dione
• CAS: 89003-36-1
• 化学式: C₁₀H₁₆N₂O₃
• 分子量: 212.249
• InChiKey: NWNSCMSYGVQKMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(吗啉-4-基甲基)哌啶-2,6-二酮 以 水 、 乙腈 为溶剂， 生成 2-hydroxy-7,9-diazatricyclo<7.4.0.0^2,7>tridec-12-en-6-one
  参考文献：
  名称：

  Coyle, John D.; Bryant, Laurence, R. B., Journal of the Chemical Society. Perkin transactions I, 1983, # 12, p. 2857 - 2865

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(1,2,5,6-tetrahydropyridin-1-ylmethyl)glutarimide 以 水 、 乙腈 为溶剂， 生成 1-(吗啉-4-基甲基)哌啶-2,6-二酮
  参考文献：
  名称：

  Coyle, John D.; Bryant, Laurence, R. B., Journal of the Chemical Society. Perkin transactions I, 1983, # 12, p. 2857 - 2865

  摘要：

  DOI：

文献信息

• SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
  作者：ANJU DAS MANIKPURI、SHEELA JOSHI、PADMAKAR V KHADIKAR

  DOI：10.4067/s0717-97072010000300001

  日期：——

  A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing H-1 NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.
• COYLE, J. D.;BRYANT, L. R. B., J. CHEM. SOC. PERKIN TRANS., 1983, N 12, 2857-2865
  作者：COYLE, J. D.、BRYANT, L. R. B.

  DOI：——

  日期：——