1-N-trityl-1,2,3,6-tetrahydropyridine | 73962-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-N-trityl-1,2,3,6-tetrahydropyridine
• 英文别名: 1-(Triphenylmethyl)-1,2,3,6-tetrahydropyridine；1-trityl-3,6-dihydro-2H-pyridine
• CAS: 73962-46-6
• 化学式: C₂₄H₂₃N
• 分子量: 325.453
• InChiKey: RHEHGMVJJSEEBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-羟基哌啶 在 偶氮二甲酸二异丙酯 、 碳酸氢钠 、 三苯基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 2.5h， 生成 1-N-trityl-1,2,3,6-tetrahydropyridine
  参考文献：
  名称：

  The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases

  摘要：

  This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.029

文献信息

• Cyclic amine derivative having heteroaryl ring
  申请人：Kimura Tomio

  公开号：US20060270706A1

  公开（公告）日：2006-11-30

  A compound having the general formula (I) wherein R 1 represents C1-C6 alkyl, etc., R 2 represents hydrogen, C2-C7 alkanoyl, C7-C11 arylcarbonyl, the formula R 4 —(CH 2 ) 1 —, etc., R 3 represents C6-C10 aryl, etc., X 1 , X 2 , X 3 , X 4 and X 5 each independently represents hydrogen, halogen, etc., and n represents an integer of 0 to 2, pharmacologically acceptable salts thereof or prodrugs thereof. They have excellent inhibition of platelet activation, etc. and are useful as a prophylactic or therapeutic agents for diseases related to thrombus or embolus formation.

  化合物具有通式（I），其中R1代表C1-C6烷基等，R2代表氢，C2-C7酰基，C7-C11芳基羰基，公式R4 -（CH2）1-等，R3代表C6-C10芳基等，X1，X2，X3，X4和X5各自独立地代表氢，卤素等，n代表0到2的整数，其药学上可接受的盐或前药。它们具有优异的抑制血小板活化等作用，并可用作与血栓或栓塞形成有关的疾病的预防或治疗剂。
• The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases
  作者：Soňa Kovačková、Martin Dračínský、Dominik Rejman

  DOI：10.1016/j.tet.2010.12.029

  日期：2011.2

  This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (C) 2010 Elsevier Ltd. All rights reserved.