3-tert-butyl-6-[(2,4-difluorobenzyl)oxy][1,2,4]triazolo[4,3-a]pyridine | 876372-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 3-tert-butyl-6-[(2,4-difluorobenzyl)oxy][1,2,4]triazolo[4,3-a]pyridine
• 英文别名: 3-Tert-butyl-6-[(2,4-difluorophenyl)methoxy]-[1,2,4]triazolo[4,3-a]pyridine
• CAS: 876372-25-7
• 化学式: C₁₇H₁₇F₂N₃O
• 分子量: 317.338
• InChiKey: KLNNFMPYPYIBAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-tert-butyl[1,2,4]triazolo[4,3-a]pyridin-6-ol 、 2,4-二氟溴苄 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以77%的产率得到3-tert-butyl-6-[(2,4-difluorobenzyl)oxy][1,2,4]triazolo[4,3-a]pyridine
  参考文献：
  名称：

  [EN] TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATION
  [FR] NOUVEAUX COMPOSES DE TRIAZOLOPYRIDINE POUR LE TRAITEMENT D'INFLAMMATION

  摘要：

  公开号：

  WO2006018727A3

文献信息

• Novel Triazolopyridine Compounds
  申请人：Rucker Paul V.

  公开号：US20090209577A1

  公开（公告）日：2009-08-20

  This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula: wherein R 1 , R 2 and R 3 , are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

  本发明通常涉及三唑并吡啶化合物，其通常抑制p38激酶、TNF和/或环氧合酶活性。这样的三唑并吡啶包括通常对应于以下结构式的化合物：其中R1、R2和R3如本说明书中所定义。本发明还涉及这种三唑并吡啶的组合物（特别是制药组合物）、合成这种三唑并吡啶的中间体、制备这种三唑并吡啶的方法，以及治疗（包括预防）与p38激酶活性、TNF活性和/或环氧合酶-2活性相关的疾病（通常是病理性疾病）的方法。
• Novel Triazolopyridine Compounds for the Treatment of Inflammation
  申请人：Rucker Paul V.

  公开号：US20090215817A1

  公开（公告）日：2009-08-27

  This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

  本发明通常涉及三唑并吡啶化合物，这些化合物通常抑制p38激酶、TNF和/或环氧合酶活性。这样的三唑并吡啶包括通常对应于以下结构式的化合物：其中R1、R2、R3、R4和R5如本规范中所定义。本发明还涉及这种三唑并吡啶的组合物（特别是药物组合物），用于合成这种三唑并吡啶的中间体，制备这种三唑并吡啶的方法，以及治疗（包括预防）与p38激酶活性、TNF活性和/或环氧合酶-2活性相关的疾病（通常是病理状况）的方法。
• SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING POLYMER OR COPOLYMER OF OLEFIN USING THE SAME
  申请人：Toho Catalyst Co., Ltd.

  公开号：EP1829898A1

  公开（公告）日：2007-09-05

  A catalyst for polymerization of olefins and a process for producing an olefin polymer or copolymer are disclosed. The catalyst comprises (a) a solid catalyst component obtained by causing an organosilicon compound (b) represented by the formula, [CH2=CH-(CH2)n]qSiR34-q, and an organoaluminum compound to come in contact with a solid component comprising magnesium, titanium, halogen, and an electron donor compound, or a solid catalyst component obtained by causing a magnesium compound, two types of titanium compounds, an electron donor compound, and an organosilicon compound to come in contact with each other, and (B) an organoaluminum compound. The process for producing an olefin polymer or copolymer comprises polymerizing olefins in the presence of the catalyst. The catalyst has a high catalytic activity, exhibits excellent hydrogen response, and can produce polymers with high stereoregularity and a broad molecular weight distribution at a high yield.

  本发明公开了一种烯烃聚合催化剂和一种生产烯烃聚合物或共聚物的工艺。该催化剂包括：(a) 一种固体催化剂组分，通过使一种由式[CH2=CH-(CH2)n]qSiR34-q表示的有机硅化合物(b)和一种有机铝化合物与一种由镁、钛、卤素和一种电子供体化合物组成的固体组分接触而得到；或一种固体催化剂组分，通过使一种镁化合物、两种钛化合物、一种电子供体化合物和一种有机硅化合物相互接触而得到；以及(B) 一种有机铝化合物。生产烯烃聚合物或共聚物的工艺包括在催化剂存在下聚合烯烃。该催化剂具有很高的催化活性，表现出优异的氢响应，并能以高产率生产出立体规整度高、分子量分布广的聚合物。
• WO2006/18735
  申请人：——

  公开号：——

  公开（公告）日：——
• TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATION
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1781655A2

  公开（公告）日：2007-05-09