4-Methyl-thiachroman | 6110-00-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 4-Methyl-thiachroman
• 英文别名: 3,4-Dihydro-4-methyl-2H-1-benzothiopyran；4-methyl-3,4-dihydro-2H-thiochromene
• CAS: 6110-00-5
• 化学式: C₁₀H₁₂S
• 分子量: 164.271
• InChiKey: HLJCDJBLHQKRNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (RS)-1-phenylthiobutan-3-ol 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以32%的产率得到4-Methyl-thiachroman
  参考文献：
  名称：

  通过热环化制备硫代色烷

  摘要：

  硫代苯并二氢吡喃环系统的形成是通过两步合成完成的，该合成涉及将3-硫代苯基-1-丙醇或4-硫代苯基-2-丁醇在甲苯中与催化量的对甲苯磺酸一起加热。丙醇是通过将硫稳定化的碳负离子添加到氧化苯乙烯，氧化乙烯，氧化丙烯和氧化异丁烯中而制得的。碳负离子是通过用丁基锂处理苄基苯基硫醚或硫代苯甲醚生成的。讨论了丙醇的1和3位取代对反应产率的影响。该反应的机理显然涉及分子内亲电子芳族取代而不是克莱森或硫代克莱森重排。

  DOI：

  10.1002/jhet.5570370619

文献信息

• [EN] INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS<br/>[FR] INHIBITEUR D'ANTAGONISTES DE LA PROTÉINE D'APOPTOSE (IAP)
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2021222614A1

  公开（公告）日：2021-11-04

  Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了调节黑色素瘤抑制凋亡蛋白（ML-IAP）活性的化合物，包括这些化合物的组合物，以及使用这些化合物和包含这些化合物的组合物的方法。
• FUNGICIDAL AMIDES
  申请人：Pasteris Robert James

  公开号：US20100004288A1

  公开（公告）日：2010-01-07

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R 1 , R 2 , A, G, W 1 , Q, X, Z, and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  本发明涉及一种公式1的化合物，包括所有的几何异构体、立体异构体、N-氧化物和其盐，其中R1、R2、A、G、W1、Q、X、Z和n如本文所定义。本发明还涉及含有公式1化合物的组合物以及通过施加本发明中化合物或组合物的有效量来控制由真菌病原体引起的植物病害的方法。
• Quinoline-2-one derivatives for the treatment of airways diseases
  申请人：Fairhurst Alec Robin

  公开号：US20070066607A1

  公开（公告）日：2007-03-22

  Compounds of formula I free or salt form, wherein —C—Y—, R 1 and R 2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β 2 -adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  化合物的公式为Ifree或盐形式，其中—C—Y—，R1和R2是G，其含义如规范中所示，对于预防或缓解通过激活β2-肾上腺素受体引起的病症是有用的。还描述了含有这些化合物的制药组合物和制备这些化合物的过程。
• FUNGICIDE N-CYCLOALKYL-N-BICYCLIC-CARBOXAMIDE DERIVATIVES
  申请人：Desbordes Philippe

  公开号：US20100197925A1

  公开（公告）日：2010-08-05

  The present invention relates N-cycloalkyl-N-bicyclic-carboxamide, thiocarboxamide or N-substituted carboximidamide derivatives of formula (I) wherein A represents a carbo-linked, 5-membered heterocyclyl group; T represents O, S, N—R a , N—OR a , N—NR a R b or N—CN; Z 1 represents a C 3 -C 7 -cycloalkyl group; X represents N or a CZ 7 and Z 2 ; Z 3 ; L 1 and L 2 represent various substituents; their process of preparation; preparation intermediate compounds; their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及公式（I）的N-环烷基-N-双环羧酰胺，硫代羧酰胺或N-取代羧酰亚胺衍生物，其中A代表一个与碳原子相连的五元杂环基团；T代表O，S，N—Ra，N—ORa，N—NRaRb或N—CN；Z1代表一个C3-C7环烷基团；X代表N或CZ7和Z2；Z3，L1和L2代表各种取代基；其制备方法；制备中间化合物；其用作杀真菌剂活性剂，特别是以杀真菌剂组成物的形式和使用这些化合物或组合物控制植物病原真菌，特别是植物的方法。
• Fungicidal Carboxamides
  申请人：Bisaha John Joseph

  公开号：US20110269712A1

  公开（公告）日：2011-11-03

  This invention is directed to compounds of Formula (1) including all geometric and stereoisomers, N oxides, and agriculturally suitable salts thereof, agricultural compositions containing them and their use as fungicides, (1) provided that the compound of Formula 1 is other than 2-[1-[(2-chlorophenyl)acetyl]-4-piperidinyl]-N-methyl-N-[(1R)-1-phenylethyl]-4-thiazolecarboxamide and R 1 is other than 4-fluorophenyl; wherein R 1 , R 2 , A, G, Q, W 1 , W 2 , X and n are otherwise as defined in the disclosure, Also disclosed are compositions containing the a compound having a formula corresponding to Formula (1) where the provisos are both omitted; and methods for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound having a formula corresponding to Formula (1) where the provisos are both omitted.

  本发明涉及公式（1）的化合物，包括所有几何和立体异构体、N-氧化物和农业适用的盐，以及包含它们的农业组成物和它们作为杀真菌剂的用途，（1）前提是公式1的化合物不是2-[1-[(2-氯苯基)乙酰基]-4-哌啶基]-N-甲基-N-[(1R)-1-苯乙基]-4-噻唑羧酰胺，且R1不是4-氟苯基；其中R1、R2、A、G、Q、W1、W2、X和n的定义如本公开说明书中所定义，还披露了含有与省略前提条件的公式（1）相对应的化合物的组合物；以及用公式（1）相应的化合物控制由真菌植物病原体引起的植物病害的方法，其中涉及施用有效量的公式（1）相应的化合物，省略前提条件。