3-phenylimidazo[2,1-b]thiazole | 32189-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: 3-phenylimidazo[2,1-b]thiazole
• 英文别名: 3-Phenyl-imidazo<2,1-b>thiazol；3-phenylimidazo[2,1-b][1,3]thiazole
• CAS: 32189-02-9
• 化学式: C₁₁H₈N₂S
• 分子量: 200.264
• InChiKey: SMEJIYARBCBMAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(1H-imidazol-2-ylsulfanyl)-1-phenylethanone 在 三氯氧磷 作用下， 生成 3-phenylimidazo[2,1-b]thiazole
  参考文献：
  名称：

  互变异构N-取代的2-苯甲酰基异硫脲溴化物

  摘要：

  由苯甲酰溴和取代的硫脲制备了许多2-苯甲酰异硫脲鎓溴化物。已经通过光谱研究了产物的互变异构性质。产品已经脱水成相应的噻唑。

  DOI：

  10.1039/j39710001667

文献信息

• Metal‐Free Synthesis of Imidazo[2,1‐ <i>b</i> ]thiazoles from Thioimidazoles and Ketones Mediated by Selectfluor
  作者：Jinwu Zhao、Qiannan Xiao、Jiaxi Chen、Jingxiu Xu

  DOI：10.1002/ejoc.202000815

  日期：2020.8.31

  Promoted by Selectfluor, imidazo[2,1‐b]thiazoles could be prepared from thioimidazoles and ketones. This metal‐free protocol was applicable to various ketones, including strong electron‐withdrawing substituted aryl ketones and alkyl ketones. Moreover, this procedure featured simple operation and easy work‐up.

  在Selectfluor的促进下，可以从硫代咪唑和酮制备咪唑并[2,1- b ]噻唑。该无金属方案适用于各种酮，包括强吸电子取代的芳基酮和烷基酮。此外，该程序具有操作简单，易于维护的特点。
• Copper-Catalyzed Synthesis of N-Fused Heterocycles through Regioselective 1,2-Aminothiolation of 1,1-Dibromoalkenes
  作者：Hui Xu、Yin Zhang、Jianqiang Huang、Wanzhi Chen

  DOI：10.1021/ol101563f

  日期：2010.8.20

  The first aminothiolation of 1,1-dibromoalkene is described using an inexpensive copper/N,N-dimethylethylenediamine catalyst. The method provides a powerful means of using easily available 1,1-dihaloalkenes as precursors to fused heterocycles.
• Studies on the imidazole series
  作者：I. A. Mazur、P. M. Kochergin

  DOI：10.1007/bf00478395

  日期：1970.4
• Small Molecule Antagonists of Xiap Family Proteins
  申请人：Chen Jianyong

  公开号：US20080021095A1

  公开（公告）日：2008-01-24

  The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
• NANOPARTICLE ARSENIC-PLATINUM COMPOSITIONS
  申请人：O'Halloran Thomas V.

  公开号：US20110020434A1

  公开（公告）日：2011-01-27

  The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer.