4-(4-iodophenyl)-4-hydroxypiperidine | 866930-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4-iodophenyl)-4-hydroxypiperidine
• 英文别名: 4-(4-iodophenyl)piperidin-4-ol；4-(4-iodo-phenyl)-piperidin-4-ol
• CAS: 866930-76-9
• 化学式: C₁₁H₁₄INO
• 分子量: 303.143
• InChiKey: GDDVZIDKWGVHFV-UHFFFAOYSA-N

物化性质

• 沸点：
  377.8±42.0 °C(Predicted)
• 密度：
  1.646±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  芦竹碱 、 4-(4-iodophenyl)-4-hydroxypiperidine 以 甲苯 为溶剂， 生成 1-((1H-indol-3-yl)methyl)-4-(4-iodophenyl)piperidin-4-ol
  参考文献：
  名称：

  Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626

  摘要：

  A series of indole, 7-azaindole, benzofuran, and benzothiophene compounds have been prepared and evaluated for affinity at D2-like dopamine receptors. These compounds share structural elements with the classical D2-like dopamine receptor antagonists haloperidol, N-methylspiperone and benperidol. Two new compounds, 4-(4-iodophenyl)-1-((4-methoxy-1H-indol-3-yl) methyl) piperidin-4-ol (6) and 4-(4-iodophenyl)-1-((5-methoxy-1H-indol-3-yl) methyl) piperidin-4-ol (7), were found to have high affinity to and selectivity for D2 versus D3 receptors. Changing the aromatic ring system from an indole to other heteroaromatic ring systems reduced the D2 binding affinity and the D2 versus D3 selectivity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.052

文献信息

• [EN] 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE ET LEUR UTILISATION EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2015132228A1

  公开（公告）日：2015-09-11

  The invention relates to antibacterial compounds of formula (I), wherein R1 is one of the groups represented below (AA), wherein A is a bond, CH=CH or C≡C; U is N or CH; V is N or CH; W represents N or CH; and R1A, R2A, R3A, R1B and R1C are as defined in the claims; and salts thereof.

  这项发明涉及公式（I）的抗菌化合物，其中R1是下面表示的一组（AA），其中A是键，CH=CH或C≡C；U是N或CH；V是N或CH；W代表N或CH；而R1A、R2A、R3A、R1B和R1C如权利要求中所定义的；以及其盐。
• Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
  申请人：Stenkamp Dirk

  公开号：US20050234101A1

  公开（公告）日：2005-10-20

  Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

  炔烃化合物具有MCH受体拮抗活性，可用于制备用于治疗代谢性疾病和/或进食障碍的药物组合物，特别是肥胖症和糖尿病。
• 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：US10106544B2

  公开（公告）日：2018-10-23

  The invention relates to antibacterial compounds of formula I wherein R1 is one of the groups represented below wherein A is a bond, CH═CH or C≡C; U is N or CH; V is N or CH; W represents N or CH; and R1A, R2A, R3A, R1B and R1C are as defined in the claims; and salts thereof.

  本发明涉及式 I 的抗菌化合物 其中 R1 是以下代表的基团之一 其中 A 是键、CH═CH 或 C≡C；U 是 N 或 CH；V 是 N 或 CH；W 代表 N 或 CH； 以及 R1A、R2A、R3A、R1B 和 R1C 如权利要求中所定义； 及其盐类。
• 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS
  申请人：Actelion Pharmaceuticals Ltd

  公开号：EP3114126A1

  公开（公告）日：2017-01-11
• US7592358B2
  申请人：——

  公开号：US7592358B2

  公开（公告）日：2009-09-22