铬-硫酸 | 773018-77-2

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物
• 中文名称: 铬-硫酸
• 英文名称: chromic-sulfuric acid
• 英文别名: chromosulfuric acid
• CAS: 773018-77-2；100730-01-6
• 化学式: CrH₂O₇S
• 分子量: 198.074
• InChiKey: VMOWPVHKUIGWKR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.53
• 重原子数：
  9.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117.97
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  铬-硫酸 以 溶剂黄146 为溶剂， 生成 chromium(VI) oxide
  参考文献：
  名称：

  Synthesis, structure, and properties of chromium(III) sulfates

  摘要：

  Reactions between CrO3 and 50-95 wt% H2SO4 are studied at temperatures up to the boiling point of the acid. Depending on the H2SO4 concentration and synthesis temperature, Cr-2(SO4)(3), CrH(SO4)(2), (H3O)[Cr(SO4)(2)], Cr-2(SO4)(3) . H2SO4 . 4H2O (gross formula), and (H5O2)[Cr(H2O)(2)(SO4)(2)], are obtained as identified reaction products in addition to the incompletely characterized chromic-sulfuric acid. The Cr-III-based sulfates are characterized by X-ray powder diffraction, thermogravimetric, and magnetic susceptibility measurements. The nuclear and magnetic structures of Cr-2(SO4)(3) at 10 K are determined, the structure type of (H3O)[Cr(SO4)(2)] is established, and the crystal structure of (H5O2)[Cr(H2O)(2)(SO4)(2)] is firmly stipulated. Magnetic susceptibility data suggest that the samples of CrH(SO4)(2) are in a micro-crystalline rather than in an amorphous state. All Cr-III-based sulfates synthesized in this study appear to undergo paramagnetic-to-antiferromagnetic transitions at around 10 K. (C) 2004 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jssc.2004.03.038
• 作为产物：
  描述：

  硫酸 、 chromium(VI) oxide 以 硫酸 为溶剂， 生成 铬-硫酸 、 chromium(III) sulfate *4H2SO4
  参考文献：
  名称：

  Synthesis, structure, and properties of chromium(III) sulfates

  摘要：

  Reactions between CrO3 and 50-95 wt% H2SO4 are studied at temperatures up to the boiling point of the acid. Depending on the H2SO4 concentration and synthesis temperature, Cr-2(SO4)(3), CrH(SO4)(2), (H3O)[Cr(SO4)(2)], Cr-2(SO4)(3) . H2SO4 . 4H2O (gross formula), and (H5O2)[Cr(H2O)(2)(SO4)(2)], are obtained as identified reaction products in addition to the incompletely characterized chromic-sulfuric acid. The Cr-III-based sulfates are characterized by X-ray powder diffraction, thermogravimetric, and magnetic susceptibility measurements. The nuclear and magnetic structures of Cr-2(SO4)(3) at 10 K are determined, the structure type of (H3O)[Cr(SO4)(2)] is established, and the crystal structure of (H5O2)[Cr(H2O)(2)(SO4)(2)] is firmly stipulated. Magnetic susceptibility data suggest that the samples of CrH(SO4)(2) are in a micro-crystalline rather than in an amorphous state. All Cr-III-based sulfates synthesized in this study appear to undergo paramagnetic-to-antiferromagnetic transitions at around 10 K. (C) 2004 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jssc.2004.03.038
• 作为试剂：
  描述：

  (3S,6R,7S,8S,12E/Z,15S,16E)-3,7,15-Tris-[[dimethyl(1,1-dimethylethyl)silyl]oxy]-4,4,8,12,16-pentamethyl-5-oxo-17-(2-pyridyl)-6-(but-3-in-1-yl)-heptadeca-12,16-dienal 在 铬-硫酸 作用下， 以 丙酮 为溶剂， 反应 1.0h， 生成 (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-tris-[[dimethyl(1,1-dimethylethyl)silyl]oxy]-4,4,8,12,16-pentamethyl-5-oxo-17-(2-pyridyl)-6-(but-3-in-1-yl)-heptadeca-12,16-dienoic acid 、 (3S,6R,7S,8S,12E,15S,16E)-3,7,15-tris-[[dimethyl(1,1-dimethylethyl)silyl]oxy]-4,4,8,12,16-pentamethyl-5-oxo-17-(2-pyridyl)-6-(but-3-in-1-yl)-heptadeca-12,16-dienoic acid
  参考文献：
  名称：

  6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations

  摘要：

  该发明描述了通式(I)中的新6-烯基-和6-炔基-epothilone衍生物，其中R1a、R1b、R2b、R3a、R3b、R4、R5、R6、R7、A、Y、D、E、G、Y和Z具有说明中指示的含义。这些新化合物通过稳定形成的微管蛋白质与微管结合。它们能够以特定阶段的方式影响细胞分裂，因此可用于治疗与细胞生长、分裂和/或增殖需求相关的疾病或状况。因此，这些化合物适用于治疗恶性肿瘤，例如卵巢、胃、结肠、腺癌、乳腺、肺、头颈癌、恶性黑色素瘤、急性淋巴细胞和骨髓性白血病。此外，它们也适用于抗血管生成治疗以及慢性炎症性疾病的治疗（如牛皮癣、关节炎）。还描述了这些化合物的使用方法和制备方法。

  公开号：

  US20050113429A1

文献信息

• Process for the preparation of 4-androstene-3,17-dione derivatives
  申请人：Schering Aktiengesellschaft

  公开号：US04100027A1

  公开（公告）日：1978-07-11

  A process for the preparation of 4-androstene-3,17-dione derivatives of the formula ##STR1## wherein X is 6,7-methylene or fluoro, chloro, or methyl in the 6- or 7-position, comprises fermenting a sterol of the formula ##STR2## wherein X is as above and R.sub.1 is a hydrocarbon residue of 8-10 carbon atoms with a microorganism culture capable of degrading the side chain of a sterol.

  一种制备4-雄烯-3,17-二酮衍生物的方法，其化学式为##STR1##其中X为6,7-亚甲基或6-位或7-位为氟、氯或甲基，包括利用一种能降解甾醇侧链的微生物培养物发酵具有化学式##STR2##其中X如上所述，R.sub.1为8-10个碳原子的烃基残基。
• Process for the preparation of androstane-3,17-dione derivatives
  申请人：Schering Aktiengesellschaft

  公开号：US04097334A1

  公开（公告）日：1978-06-27

  A process for the preparation of androstane-3,17-dione compounds of the formula ##STR1## wherein X is 1,2-methylene or 1- or 2-methyl, comprises fermenting a sterol of the formula ##STR2## wherein X is as above and R.sub.1 is the hydrocarbon residue of 8-10 carbon atoms, of a sterol, with a microorganism culture capable of effecting the side chain degradation of sterols.

  一种制备雄烷-3,17-二酮化合物的方法，其化学式为##STR1##其中X为1,2-亚甲基或1-或2-甲基，包括利用一种能够使甾醇的侧链降解的微生物培养物发酵具有化学式##STR2##其中X如上所述，R.sub.1为8-10个碳原子的烃残基的甾醇。
• Novel methylene steroids
  申请人：Schering Aktiengesellschaft

  公开号：US04012510A1

  公开（公告）日：1977-03-15

  Methylene steroids of the formula ##STR1## wherein X is H, F or CH.sub.3 ; Y is hydroxymethylene, alkanoyloxymethylene or carbonyl; R.sub.1 is H, OH or alkanoyloxy; and R.sub.2 is H, OH or esterified OH, possess topical anti-inflammatory activity.

  其中X为H，F或CH3；Y为羟甲基，烷酰氧甲基或羰基；R1为H，OH或烷酰氧基；R2为H，OH或酯化的OH的亚甲基类固醇具有局部抗炎活性。