Chlortris(4-fluorphenyl)methan | 379-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Chlortris(4-fluorphenyl)methan
• 英文别名: 4,4',4''-trifluoro-trityl chloride；4,4',4''-Trifluor-tritylchlorid；1,1',1''-(Chloromethanetriyl)tris(4-fluorobenzene)；1-[chloro-bis(4-fluorophenyl)methyl]-4-fluorobenzene
• CAS: 379-56-6
• 化学式: C₁₉H₁₂ClF₃
• 分子量: 332.752
• InChiKey: OTQAIHOEFHAQDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  Chlortris(4-fluorphenyl)methan 生成 hexakis-(4-fluoro-phenyl)-ethane
  参考文献：
  名称：

  The Dissociation of Hexaarylethanes. XVI.¹ Alkyl and Halogen Derivatives

  摘要：

  DOI：

  10.1021/ja01234a023
• 作为产物：
  描述：

  对氟苯甲酸甲酯 在 盐酸 、 乙醚 、 Petroleum ether 作用下， 生成 Chlortris(4-fluorphenyl)methan
  参考文献：
  名称：

  THE REACTIVITY OF PARA-FLUORINE IN TRIARYLMETHYL CHLORIDES

  摘要：

  DOI：

  10.1021/jo01220a011

文献信息

• Potassium channel modulators
  申请人：Gouliaev Haahr Alex

  公开号：US20050009816A1

  公开（公告）日：2005-01-13

  This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SK Ca and/or IK Ca channels.

  本发明涉及一种新型化合物，可用作钾通道调节剂。更具体地，本发明提供了化学化合物，可用作SKCa和/或IKCa通道的调节剂。
• Bartroli; Alguero; Boncompte, Arzneimittel-Forschung/Drug Research, 1992, vol. 42, # 6, p. 832 - 835
  作者：Bartroli、Alguero、Boncompte、Forn

  DOI：——

  日期：——
• Novel Inhibitors of the Gardos Channel for the Treatment of Sickle Cell Disease
  作者：Grant A. McNaughton-Smith、J. Ford Burns、Jonathan W. Stocker、Gregory C. Rigdon、Christopher Creech、Susan Arrington、Tara Shelton、Lucia de Franceschi

  DOI：10.1021/jm070663s

  日期：2008.2.1

  Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal hemoglobin that polymerizes upon deoxygenation. This effect is exacerbated when dehydrated RBCs experience a loss of both water and potassium salts. One critical pathway for the regulation of potassium efflux from RBCs is the Gardos channel, a calcium-activated potassium channel. This paper describes the synthesis and biological evaluation of a series of potent inhibitors of the Gardos channel. The goal was to identify compounds that were potent and selective inhibitors of the channel but had improved pharmacokinetic properties compared to 1, Clotrimazole. Several triarylamides such as 10 and 21 were potent inhibitors of the Gardos channel (IC50 of < 10 nM) and active in a mouse model of SCD. Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.
• Blumenstock, H.; Dickert, F.; Fackler, H., Zeitschrift fur physikalische Chemie (Neue Folge), 1983, vol. 135, p. 157 - 170
  作者：Blumenstock, H.、Dickert, F.、Fackler, H.、Hammerschmidt, A.

  DOI：——

  日期：——
• Duennebacke, Dieter; Neumann, Wilhelm P.; Penenory, Alicia, Chemische Berichte, 1989, vol. 122, p. 533 - 536
  作者：Duennebacke, Dieter、Neumann, Wilhelm P.、Penenory, Alicia、Stewen, Ulrich

  DOI：——

  日期：——