Diethylmethylpiperidinomethan | 14045-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Diethylmethylpiperidinomethan
• 英文别名: 1-(1-ethyl-1-methyl-propyl)-piperidine；1-(1-Aethyl-1-methyl-propyl)-piperidin；1-(3-Methylpentan-3-yl)piperidine
• CAS: 14045-26-2
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: SBNGBXSJNPGFQS-UHFFFAOYSA-N

物化性质

• 沸点：
  218.64°C (estimate)
• 密度：
  0.8614

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙基溴化镁 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 Diethylmethylpiperidinomethan
  参考文献：
  名称：

  Bruylants, Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1925, vol. <5> 11, p. 269

  摘要：

  DOI：

文献信息

• Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
  申请人：Nurix Therapeutics, Inc.

  公开号：US11530229B2

  公开（公告）日：2022-12-20

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

  本发明公开了用于抑制泛素蛋白酶体途径中的 E3 酶 Cbl-b 的化合物、组合物和方法。这些化合物、组合物和方法可用于调节免疫系统，治疗免疫系统可调节的疾病，以及体内、体外或体外细胞的治疗。还公开了包含 Cbl-b 抑制剂和癌症疫苗的药物组合物，以及使用 Cbl-b 抑制剂和癌症疫苗治疗癌症的方法；以及包含 Cbl-b 抑制剂和溶瘤病毒的药物组合物，以及使用 Cbl-b 抑制剂和溶瘤病毒治疗癌症的方法。
• CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF
  申请人：Nurix Therapeutics, Inc.

  公开号：US20210053986A1

  公开（公告）日：2021-02-25

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
• QUINOLINE CARBOXYLATE COMPOUND AND PREPARATION METHOD AND USE THEREOF
  申请人：SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD.

  公开号：US20220220076A1

  公开（公告）日：2022-07-14

  A quinoline carboxylate compound of the following formula (I): The compound of formula (I) shows good activity against various bacteria in agricultural field.