7-hydroxy-8-methyl-6-((4-methylpiperazin-1-yl)methyl)-4-phenyl-2H-chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 7-hydroxy-8-methyl-6-((4-methylpiperazin-1-yl)methyl)-4-phenyl-2H-chromen-2-one
• 英文别名: 7-hydroxy-8-methyl-6-[(4-methylpiperazin-1-yl)methyl]-4-phenylchromen-2-one
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.444
• InChiKey: KUUOJVCTIFCRDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  53
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-甲基-4-[(4-甲基哌嗪-1-基)甲基]哌嗪 、 7-羟基-8-甲基-4-苯基-2H-色烯-2-酮 以 1,4-二氧六环 为溶剂， 以86%的产率得到7-hydroxy-8-methyl-6-((4-methylpiperazin-1-yl)methyl)-4-phenyl-2H-chromen-2-one
  参考文献：
  名称：

  摘要：

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.

  DOI：

  10.1023/a:1002835422747

文献信息

• ——
  作者：M. M. Garazd、Ya. L. Garazd、S. V. Shilin、V. P. Khilya

  DOI：10.1023/a:1002835422747

  日期：——

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.