7-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-methoxymethyl-5-methyl-2-methylsulfanyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one | 103949-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 7-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-methoxymethyl-5-methyl-2-methylsulfanyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one
• 英文别名: 7-((3aR,4S,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-methoxymethyl-5-methyl-2-methylsulfanyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one；3,4-dihydro-3-methoxymethyl-5-methyl-2-methylthio-7-(2,3-O-isopropylidene-5-O-triphenylmethyl-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4-one；3,4-dihydro-3-methoxymethyl-5-methyl-2-methylthio-7-(2,3-O-isopropylidene-5-O-triphenylmethyl-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-one
• CAS: 103949-72-0；103949-73-1
• 化学式: C₃₇H₃₉N₃O₆S
• 分子量: 653.799
• InChiKey: LURINSLDFGHOEP-GDKRABATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  47.0
• 可旋转键数：
  10.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  85.97
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  乙酰胺 、 7-((3aR,4R,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-methoxymethyl-5-methyl-2-methylsulfanyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 在 sodium hydride 作用下， 反应 2.5h， 生成 N-[7-[(3aR,4S,6R,6aR)-2,2-dimethyl-6-(trityloxymethyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-(methoxymethyl)-5-methyl-4-oxopyrrolo[2,3-d]pyrimidin-2-yl]acetamide 、 N-[7-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(trityloxymethyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-(methoxymethyl)-5-methyl-4-oxopyrrolo[2,3-d]pyrimidin-2-yl]acetamide
  参考文献：
  名称：

  A total synthesis of cadeguomycin, a nucleoside antibiotic produced by

  摘要：

  DOI：

  10.1016/s0040-4020(01)87418-4