(i-bu)2Si(OH)2 | 18230-63-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (i-bu)2Si(OH)2
• 英文别名: diisobutyl-silanediol；Diisobutyl-silandiol；diisobutyl silanediol；diisobutylsilanediol；Di-isobutylsilandiol；dihydroxy-bis(2-methylpropyl)silane
• CAS: 18230-63-2
• 化学式: C₈H₂₀O₂Si
• 分子量: 176.331
• InChiKey: UKSWSALBYQIBJN-UHFFFAOYSA-N

物化性质

• 熔点：
  100-101 °C
• 沸点：
  238.2±23.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.73
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (i-bu)2Si(OH)2 、 三甲基氯硅烷 、 正丁基锂 以65%的产率得到
  参考文献：
  名称：

  GRAALMANN, O.;KLINGEBIEL, U.;CLEGG, W.;HAASE, M.;SHELDRICK, G. M., CHEM. BER., 1984, 117, N 9, 2988-2997

  摘要：

  DOI：
• 作为产物：
  描述：

  二异丁基二甲氧基硅烷 在 盐酸 水 作用下， 以 异丙醇 为溶剂， 反应 24.0h， 以70%的产率得到(i-bu)2Si(OH)2
  参考文献：
  名称：

  Silane-based Resins That Can Be Photochemically And/or Thermally Structured, Single-step Method for Their Production, Parent Compounds and Production Methods That Can Be Used for Said Resins

  摘要：

  通过至少部分缩合以下混合物获得可以通过光化学和/或热化学结构化的硅烷树脂：a）至少一种硅烷化合物RaR2bSiX4-a-b，其中R是通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团；R2是直链，分支或环状C1-C12烷基基团；X是相同或不同的离去基团；a为1或2；b为0或1；a+b不超过2；和b）至少一种硅醇R12Si（OH）2，其中R1是相同或不同的直链，分支或环状C1-C12烷基基团或通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团，但该基团不含芳基。这些硅烷树脂具有在极高频应用中有用的介电性能。

  公开号：

  US20080194856A1

文献信息

• Silane-based Resins That Can Be Photochemically And/or Thermally Structured, Single-step Method for Their Production, Parent Compounds and Production Methods That Can Be Used for Said Resins
  申请人：Frohlich Lothar

  公开号：US20080194856A1

  公开（公告）日：2008-08-14

  A silane resin that can be structured photochemically and/or thermally is obtained by at least partial condensation of a mixture of a) at least one silane compound R a R 2 b SiX 4-a-b wherein R is a group polymerizable photochemically and/or thermally via an organic group by radical or cationic polymerization; R 2 is a straight-chain, branched, or cyclic C 1 -C 12 alkyl group; X is identical or different and is a leaving group; a is 1 or 2; b is 0 or 1; a+b is not more than 2; and b) at least one silanediol R 1 2 Si(OH) 2 wherein R 1 is identical or different and is a straight-chain, branched, or cyclic C 1 -C 12 alkyl group or a group polymerizable photochemically and/or thermally via an organic group by radical or cationic polymerization, provided the group does not contain aryl. The silane resins have dielectric properties useful in extremely high frequency applications.

  通过至少部分缩合以下混合物获得可以通过光化学和/或热化学结构化的硅烷树脂：a）至少一种硅烷化合物RaR2bSiX4-a-b，其中R是通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团；R2是直链，分支或环状C1-C12烷基基团；X是相同或不同的离去基团；a为1或2；b为0或1；a+b不超过2；和b）至少一种硅醇R12Si（OH）2，其中R1是相同或不同的直链，分支或环状C1-C12烷基基团或通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团，但该基团不含芳基。这些硅烷树脂具有在极高频应用中有用的介电性能。
• Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study
  作者：Maureen J O'Sullivan、Michael Kyriakos、Xiaopei Zhu、Mark R Wick、Paul E Swanson、Louis P Dehner、Paul A Humphrey、John D Pfeifer

  DOI：10.1038/modpathol.3880230

  日期：2000.11

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.
• Eaborn, C., Journal of the Chemical Society
  作者：Eaborn, C.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 86, page 235 - 238
  作者：

  DOI：——

  日期：——
• WEIDENBRUCH M.; SCHAEFER A.; RANKERS R., J. ORGANOMETAL. CHEM., 1980, 195, NO 2, 171-184
  作者：WEIDENBRUCH M.、 SCHAEFER A.、 RANKERS R.

  DOI：——

  日期：——