VUF 5745 | 193355-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: VUF 5745
• 英文别名: 4-(p-chlorophenyl)-1-(3-phenylpropyl)piperidin-4-ol；4-(4-Chlorophenyl)-4-hydroxy-1-(3-phenylpropyl)piperidine；VUF5745；4-(4-Chlorophenyl)-1-(3-phenylpropyl)-4-piperidinol；4-(4-chlorophenyl)-1-(3-phenylpropyl)piperidin-4-ol
• CAS: 193355-50-9
• 化学式: C₂₀H₂₄ClNO
• 分子量: 329.87
• InChiKey: WFQAUBWSHNCWHT-UHFFFAOYSA-N

物化性质

• 沸点：
  480.8±45.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(4-氯苯基)-4-羟基哌啶 、 1-溴-3-苯基丙烷 生成 VUF 5745
  参考文献：
  名称：

  US6124323

  摘要：

  公开号：

文献信息

• Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28
  作者：Janneke W. Hulshof、Henry F. Vischer、Mark H.P. Verheij、Silvina A. Fratantoni、Martine J. Smit、Iwan J.P. de Esch、Rob Leurs

  DOI：10.1016/j.bmc.2006.06.054

  日期：2006.11

  G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse agonists acting on the HCMV-encoded receptor US28. It is shown that replacement of the 4-hydroxy group of lead compound I with a methylamine group results in a significant 6-fold increase in affinity. Interestingly, increasing the rigidity of the spacer by the introduction of a double bond also leads to a significant increase in binding affinity compared to 1. These novel inverse agonists serve as valuable tools to elucidate the role of constitutive signaling in the pathogenesis of viral infection and may have therapeutic potential as leads for new antiviral drugs. (c) 2006 Elsevier Ltd. All rights reserved.
• Synthesis of N-ω-Phenylalkyl-4-(p-chlorophenyl)-piperidin-4-ol Analogues with Potent Antiproliferative Activity Against HCT-116 Cells
  作者：Noriyuki Hatae、Teruki Yoshimura、Eiko Kujime、Keigo Yano、Mami Kizuka、Rina Ashida、Tominari Choshi、Takashi Nishiyama、Chiaki Okada、Tatsunori Iwamura

  DOI：10.3987/com-18-s(t)25

  日期：——

  Some opioid analogues, such as morphine and loperamide, were reported to exhibit weak antiproliferative activity against tumor cells. In a study of loperamide analogues, we found that adding an N-omega-phenylalkyl group onto the 4-arylpiperidin-4-ol unit can have important effects on the antiproliferative activity of such compounds against HCT-116 cells. We optimized the distance between the phenyl group and 4-arylpiperidin unit to promote such activity.
• EP0869792A4
  申请人：——

  公开号：EP0869792A4

  公开（公告）日：1999-09-22
• 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0869792A2

  公开（公告）日：1998-10-14
• US6124323A
  申请人：——

  公开号：US6124323A

  公开（公告）日：2000-09-26