2-[(2-hydroxy-phenylimino)-methyl]-4-(4-chloro-2-nitro-phenylazo)-phenol | 1367182-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 2-[(2-hydroxy-phenylimino)-methyl]-4-(4-chloro-2-nitro-phenylazo)-phenol
• 英文别名: 2-[(2-hydroxyphenylimino)methyl]-4-(4-chloro-2-nitrophenylazo)phenol
• CAS: 1367182-20-4
• 化学式: C₁₉H₁₃ClN₄O₄
• 分子量: 396.79
• InChiKey: YWUJHWTXONBGIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120.68
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-[(2-hydroxy-phenylimino)-methyl]-4-(4-chloro-2-nitro-phenylazo)-phenol 、 zinc diacetate 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 以50%的产率得到(Zn(2-[(2-hydroxy-phenylimino)-methyl]-4-(4-chloro-2-nitro-phenylazo)-phenol(2-)))2
  参考文献：
  名称：

  Synthesis and Biological Activity Evaluation of Some Binuclear Metal Complexes of Cu(II) and Zn(II) with Tridentate Schiff Base Ligands

  摘要：

  A few kinds of new Schiff bases were synthesized by reaction of 2-aminophenol and corresponding synthesized azo compounds 3a-e. Further reaction of these Schiff bases 4a-e with transition metal salts as Cu(II) and Zn(II) gave corresponding binuclear complexes 5a-e and 6a-e. The antibacterial activity of prepared complexes was investigated against Staphylococcus aureus and Escherichia coli bacteria. The results for some compounds revealed a moderate to good inhibition against Staphylococcus aureus compared with penicillin zone of inhibition.

  DOI：

  10.1080/15533174.2011.609512
• 作为产物：
  描述：

  1-(3-formyl-4-hydroxyphenylazo)-4-chloro-2-nitrobenzene 、 2-氨基苯酚 在 copper(II) nitrate trihydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以86%的产率得到2-[(2-hydroxy-phenylimino)-methyl]-4-(4-chloro-2-nitro-phenylazo)-phenol
  参考文献：
  名称：

  Synthesis and Biological Activity Evaluation of Some Binuclear Metal Complexes of Cu(II) and Zn(II) with Tridentate Schiff Base Ligands

  摘要：

  A few kinds of new Schiff bases were synthesized by reaction of 2-aminophenol and corresponding synthesized azo compounds 3a-e. Further reaction of these Schiff bases 4a-e with transition metal salts as Cu(II) and Zn(II) gave corresponding binuclear complexes 5a-e and 6a-e. The antibacterial activity of prepared complexes was investigated against Staphylococcus aureus and Escherichia coli bacteria. The results for some compounds revealed a moderate to good inhibition against Staphylococcus aureus compared with penicillin zone of inhibition.

  DOI：

  10.1080/15533174.2011.609512