(2R,3R,4S,5R,6S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-phenoxy-4,5-bis[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxan-3-ol | 1000853-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2R,3R,4S,5R,6S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-phenoxy-4,5-bis[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxan-3-ol
• CAS: 1000853-40-6
• 化学式: C₆₃H₇₈O₁₆
• 分子量: 1091.3
• InChiKey: NNOXRPCSKCLCMX-VMBFQWSBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  79
• 可旋转键数：
  40
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5R,6S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-phenoxy-4,5-bis[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxan-3-ol 、 2-氯苯基二氯膦 在 吡啶 、 1H-1,2,4-三唑 、 三乙胺 、 水 作用下， 以 氯仿 为溶剂， 以92%的产率得到2-chlorophenyl ((2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-phenoxy-4,5-bis((1-phenyl-2,5,8,11-tetraoxatridecan-13-yl)oxy)tetrahydro-2H-pyran-3-yl) hydrogen phosphate
  参考文献：
  名称：

  Novel Amphiphilic Cyclic Oligosaccharides:  Synthesis and Self-Aggregation Properties

  摘要：

  [GRAPHICS]Novel amphiphilic cyclic disaccharide analogues, in which the saccharide units are connected through stable phosphodiester linkages (CyPLOS, Cyclic Phosphate-Linked OligoSaccharides) and decorated with long lipophilic tentacles at the 2- and 3-OH moieties, have been synthesized. Their propensity to self-aggregation has been investigated by means of H-1 and P-31 NMR experiments, making it possible to determine for these macrocycles critical aggregation concentration values in the,millimolar range.

  DOI：

  10.1021/jo7017087
• 作为产物：
  描述：

  (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-phenoxy-4,5-bis[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxan-3-ol 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 以98%的产率得到(2R,3R,4S,5R,6S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-phenoxy-4,5-bis[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxan-3-ol
  参考文献：
  名称：

  Novel Amphiphilic Cyclic Oligosaccharides:  Synthesis and Self-Aggregation Properties

  摘要：

  [GRAPHICS]Novel amphiphilic cyclic disaccharide analogues, in which the saccharide units are connected through stable phosphodiester linkages (CyPLOS, Cyclic Phosphate-Linked OligoSaccharides) and decorated with long lipophilic tentacles at the 2- and 3-OH moieties, have been synthesized. Their propensity to self-aggregation has been investigated by means of H-1 and P-31 NMR experiments, making it possible to determine for these macrocycles critical aggregation concentration values in the,millimolar range.

  DOI：

  10.1021/jo7017087

文献信息

• Novel Amphiphilic Cyclic Oligosaccharides:  Synthesis and Self-Aggregation Properties
  作者：Cinzia Coppola、Vittorio Saggiomo、Giovanni Di Fabio、Lorenzo De Napoli、Daniela Montesarchio

  DOI：10.1021/jo7017087

  日期：2007.12.1

  [GRAPHICS]Novel amphiphilic cyclic disaccharide analogues, in which the saccharide units are connected through stable phosphodiester linkages (CyPLOS, Cyclic Phosphate-Linked OligoSaccharides) and decorated with long lipophilic tentacles at the 2- and 3-OH moieties, have been synthesized. Their propensity to self-aggregation has been investigated by means of H-1 and P-31 NMR experiments, making it possible to determine for these macrocycles critical aggregation concentration values in the,millimolar range.