2-羟基-4-(2-羟基-4-甲氧基-6-丙基苯甲酰氧基)-6-丙基苯甲酸 | 491-62-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 2-羟基-4-(2-羟基-4-甲氧基-6-丙基苯甲酰氧基)-6-丙基苯甲酸
• 英文名称: divaricatic acid
• 英文别名: divericatic acid；Divaricatsaeure；2-hydroxy-4-(2-hydroxy-4-methoxy-6-propyl-benzoyloxy)-6-propyl-benzoic acid；2-Hydroxy-4-(2-hydroxy-4-methoxy-6-propyl-benzoyloxy)-6-propyl-benzoesaeure；2-hydroxy-4-(2-hydroxy-4-methoxy-6-propylbenzoyl)oxy-6-propylbenzoic acid
• CAS: 491-62-3
• 化学式: C₂₁H₂₄O₇
• 分子量: 388.417
• InChiKey: FSRDIJIAQPSMMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-羟基-4-(2-羟基-4-甲氧基-6-丙基苯甲酰氧基)-6-丙基苯甲酸 在 氢氧化钾 作用下， 生成 2-hydroxy-4-methoxy-6-propylbenzoic acid
  参考文献：
  名称：

  Asahina; Akagi, Chemische Berichte, 1935, vol. 68, p. 1130,1132

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 2-羟基-4-(2-羟基-4-甲氧基-6-丙基苯甲酰氧基)-6-丙基苯甲酸
  参考文献：
  名称：

  Effects of cancer and anti-neoplastic treatment on the human testicular function

  摘要：

  Men with testicular neoplasia (TN) and Hodgkin's disease (HD) are those who more frequently require treatment for fertility because these malignancies affect patients during the reproductive age and because the early diagnosis and the improved anti-neoplastic treatments cure most of these patients. Although some of them can father a child spontaneously, assisted reproductive techniques allow fatherhood to patients with severe spermatogenesis impairment and this possibility has raised concern about the long-term consequence of the testicular damage induced by chemo- and/or radiotherapy. This paper reviews the effects of cancer per se and of anti-neoplastic treatments on gonadal function, sperm aneuploidy rate and sperm DNA integrity. A debate is still open as to whether TN or HD per se may impair spermatogenesis. Many studies have shown that this is the case, albeit others have challenged this view. Chemo- and/or radiotherapy affects negatively gonadal function, rendering almost all patients azoospermics. However, spontaneous pregnancies and a high degree of spermatogenesis recovery occur with time. A large body of literature on sperm chromosome complement suggests an increased rate of structural and numerical chromosome abnormalities in patients with cancer during anti-neoplastic treatment. A minority of them has, however, shown that this effect disappears with time. An interesting and relatively new aspect is the study of sperm DNA integrity in patients with TN and HD particularly following chemo- and/or radiotherapy. The scanty information available seems to suggest that these patients have a permanent or at least a long-lasting DNA fragmentation in their spermatozoa. (C) 2000, Editrice Kurtis.

  DOI：

  10.1007/bf03343795

文献信息

• 3-Chlordivaricatsäure, ein neues depsid aus Thelomma-arten
  作者：Siegfried Huneck、Goran Sundholm、Gerhard Follmann

  DOI：10.1016/0031-9422(80)87031-2

  日期：1980.1

  Abstract The structure of 3-chlorodivaricatic acid, a new depside from the lichen Thelomma mammosum was elucidated by 1H NMR, 13C NMR, mass and UV spectroscopy. The synthesis of 5-chlorodivaricatic acid is described.

  摘要 利用1H NMR、13C NMR、质谱和紫外光谱对乳香地衣中的一种新分泌物3-氯二戊二酸的结构进行了阐明。描述了 5-氯二酸的合成。
• Un marco biológico para entender el fitomejoramiento de los agricultures
  作者：David A. Cleveland、Soleri Daniela、Steven E. Smith

  DOI：10.1007/bf02864788

  日期：2000.7

  We present a framework for understanding farmer plant breeding (including both choice of varieties and populations and plant selection) in terms of the basic biological model of scientific plant breeding, focusing on three key components of that model: 1) genetic variation, 2) environmental variation and variation of genotype-by-envivonment interaction, and 3) plant selection. For each of these concepts we suggest questions for research on fanners' plant breeding (farmers' knowledge, practice, and crop varieties and growing environments). A sample of recent research shows a range of explicit and implicit answers to these questions which are often contradictory, suggesting that generalizations based on experience with specific varieties, environments or farmers may not be valid. They also suggest that farmers' practice reflects an understanding of their crop varieties and populations that is in many ways fundamentally similar to that of plant breeders; yet, is also different, in part because the details of their experiences are different. Further research based on this framework should be valuable for participatory or collaborative plant breeding that is currently bring proposed to reunite farmer and scientific plans breeding.
• Asahina; Hirakata, Chemische Berichte, 1932, vol. 65, p. 1665,1667
  作者：Asahina、Hirakata

  DOI：——

  日期：——
• Zopf,W., Justus Liebigs Annalen der Chemie, 1898, vol. 300, p. 330
  作者：Zopf,W.

  DOI：——

  日期：——
• Hesse, Journal fur praktische Chemie (Leipzig 1954), 1911, vol. <2> 83, p. 34,38
  作者：Hesse

  DOI：——

  日期：——