(4R)-4-ethyl-2-methyl-4,5-dihydro-1,3-oxazole | 116173-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: (4R)-4-ethyl-2-methyl-4,5-dihydro-1,3-oxazole
• CAS: 116173-82-1
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: BTNAATRNKJRBCS-ZCFIWIBFSA-N

物化性质

• 沸点：
  132.9±9.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R)-4-ethyl-2-methyl-4,5-dihydro-1,3-oxazole 在 tetraphosphorus decasulfide 作用下， 以 二氯甲烷 为溶剂， 反应 140.0h， 以32%的产率得到(4R)-4-ethyl-2-methyl-4,5-dihydro-1,3-thiazole
  参考文献：
  名称：

  Aitken, R. Alan; Armstrong, David P.; Galt, Ronald H. B., Journal of the Chemical Society. Perkin transactions I, 1997, # 6, p. 935 - 943

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基丁醇 、 乙基乙酰亚胺盐酸盐 以 二氯甲烷 为溶剂， 反应 72.0h， 以52%的产率得到(4R)-4-ethyl-2-methyl-4,5-dihydro-1,3-oxazole
  参考文献：
  名称：

  Aitken, R. Alan; Armstrong, David P.; Galt, Ronald H. B., Journal of the Chemical Society. Perkin transactions I, 1997, # 6, p. 935 - 943

  摘要：

  DOI：

文献信息

• Diagnostic agents for positron emission imaging using F-18 radio labeled amino-alcohols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2036578A1

  公开（公告）日：2009-03-18

  This invention relates to novel compounds F-18 radio-labeled amino-alcohols suitable for labeling or already labeled by 18F methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

  本发明涉及一种新型化合物F-18放射性标记的氨基醇，适用于标记或已经通过18F方法标记的制备该化合物的方法，包含该化合物的组合物，包含该化合物或组合物的试剂盒以及这种化合物、组合物或试剂盒用于正电子发射断层摄影（PET）的诊断成像的用途。
• New synthesis of β-amino acids by nucleophilic addition of enolate anions to N-methoxycarbonylimines generated from α-methoxy carbamates1
  作者：Tatsuya Shono*、Naoki Kise、Fumio Sanda、Satoru Ohi、Kenji Tsubata

  DOI：10.1016/s0040-4039(00)80062-3

  日期：1988.1
• Asymmetric hetero-Diels–Alder reactions. Reactions of oxazolo[3,2- c ]pyrimidines
  作者：Mark C Elliott、Elbertus Kruiswijk、David J Willock

  DOI：10.1016/s0040-4020(01)01032-8

  日期：2001.12

  Diastereomerically pure oxazolo[3,2-c]pyrimidines can be readily prepared by the reaction of alkenyloxazolines with isocyanates. The mechanism of this transformation has been investigated computationally. These compounds undergo epimerisation upon prolonged heating, a reaction which is consistent with the proposed stepwise mechanism. Hydrolysis reactions of these compounds have been investigated. (C) 2001 Elsevier Science Ltd. All rights reserved.
• SHONO, TATSUYA;KISE, NAOKI;SANDA, FUMIO;OHI, SATORU;TSUBATA, KENJI, TETRAHEDRON LETT., 29,(1988) N 2, 231-234
  作者：SHONO, TATSUYA、KISE, NAOKI、SANDA, FUMIO、OHI, SATORU、TSUBATA, KENJI

  DOI：——

  日期：——
• [EN] DIAGNOSTIC AGENTS FOR POSITRON EMISSION IMAGING USING F-18 RADIO-LABELED AMINO-ALCOHOLS<br/>[FR] AGENTS DE DIAGNOSTIC POUR L'IMAGERIE PAR ÉMISSION DE POSITRON À L'AIDE D'AMINOALCOOLS RADIOMARQUÉS PAR 18F
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2009033584A2

  公开（公告）日：2009-03-19

  This invention relates to novel compounds F-18 radio-labeled amino-alcohols suitable for labeling or already labeled by 18F methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).