bis-(5-chloro-[2]thienyl)-ether

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: bis-(5-chloro-[2]thienyl)-ether
• 英文别名: Bis-(5-chlor-[2]thienyl)-aether；2-Chloro-5-[(5-chlorothiophen-2-yl)methoxymethyl]thiophene
• 化学式: C₁₀H₈Cl₂OS₂
• 分子量: 279.211
• InChiKey: YTUOJKYFHZTTKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-5-氯甲基噻吩 在 sodium hydroxide 、 sodium acetate 作用下， 生成 bis-(5-chloro-[2]thienyl)-ether 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  THE PREPARATION OF 2-THIOPHENEALDEHYDE AND SOME OF ITS DERIVATIVES

  摘要：

  DOI：

  10.1021/jo01157a011

文献信息

• BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1140896A1

  公开（公告）日：2001-10-10
• US6235771B1
  申请人：——

  公开号：US6235771B1

  公开（公告）日：2001-05-22
• [EN] BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5<br/>[FR] DERIVES DE BENZOTHIEPIN-ANILIDE, PRODUCTION ET UTILISATION COMME ANTAGONISTE DE CCR-5
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2000037455A1

  公开（公告）日：2000-06-29

  This invention is to provide compound of formula (I) wherein R1 is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of formula (a); wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R?5 and R6¿ are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R?5 and R6¿ may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof, which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.
• THE PREPARATION OF 2-THIOPHENEALDEHYDE AND SOME OF ITS DERIVATIVES
  作者：WILLIAM S. EMERSON、TRACY M. PATRICK

  DOI：10.1021/jo01157a011

  日期：1949.9