N,N'-bis(trimethylsilyl)-N,N'-dimethylethylene-1,2-diamine | 1821-97-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: N,N'-bis(trimethylsilyl)-N,N'-dimethylethylene-1,2-diamine
• 英文别名: N,N'-bis-(trimethylsilyl)-N,N'-dimethyl-ethylenediamine；N,N'-dimethyl-N,N'-bis(trimethylsilyl)ethylenediamine；N,N'-dimethyl-N,N'-bis(trimethylsilyl)ethanediamine；N,N'-dimethyl-N,N'-bis-trimethylsilyl-ethylenediamine；N,N'-Dimethyl-N,N'-bis-(trimethylsilyl)-ethylendiamin；N,N'-Dimethyl-N,N'-bis-trimethylsilyl-ethylendiamin；1,2-Ethanediamine, N,N'-dimethyl-N,N'-bis(trimethylsilyl)-；N,N'-dimethyl-N,N'-bis(trimethylsilyl)ethane-1,2-diamine
• CAS: 1821-97-2
• 化学式: C₁₀H₂₈N₂Si₂
• 分子量: 232.517
• InChiKey: WQNZKMJHQBIKKO-UHFFFAOYSA-N

物化性质

• 沸点：
  211-212 °C
• 密度：
  0.8249 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-bis(trimethylsilyl)-N,N'-dimethylethylene-1,2-diamine 在 三氯化磷 作用下， 以91%的产率得到2-chloro-1,3-dimethyl-1,3,2-diazaphospholidine
  参考文献：
  名称：

  1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP): a powerful condensing reagent for phosphate and phosphonate esters

  摘要：

  A novel phosphonium-type condensing reagent, 1,3-dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP), was designed and synthesized. A P-31 NMR study oil the condensation reactions of phosphate, alkylphosphonate , boranophosphate, and H-phosphonate derivatives with an alcohol in the presence of MNTP demonstrated the versatility and the enhanced activity of the new condensing reagent, compared to the previously reported phosphonium-type condensing reagents. The mechanism of the condensation reactions mediated by MNTP is discussed on the basis of the P-31 NMR studies and theoretical calculations. (c) 2006 Elsevier Ltd. All rights, reserved.

  DOI：

  10.1016/j.tet.2006.01.084
• 作为产物：
  描述：

  三甲基氯硅烷 、 N,N'-二甲基乙二胺 在 三乙胺 作用下， 以 苯 为溶剂， 生成 N,N'-bis(trimethylsilyl)-N,N'-dimethylethylene-1,2-diamine
  参考文献：
  名称：

  Gol'din,G.S. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2492 - 2494

  摘要：

  DOI：

文献信息

• A new synthetic procedure for the convenient preparation of thiocarbamoyl chlorides and the novel bis-thiocarbamoyl chlorides
  作者：Sámal Jens í Skorini、Alexander Senning

  DOI：10.1016/0040-4020(80)80032-9

  日期：1980.1

  good yields and excellent purity. This method was also suitable for preparing the first bis-thiocarbamoyl chlorides from N,N'-bis(trimethylsilyl)-diamines. Bis-thiocarbamoyl chlorides are useful synthetic intermediates.

  用过量的硫光气处理N-甲硅烷基胺可得到高收率和极好的纯度的硫代氨基甲酰氯。该方法也适合于由N，N′-双（三甲基甲硅烷基）-二胺制备第一双-硫代氨基甲酰氯。双硫代氨基甲酰氯是有用的合成中间体。
• Conformational Properties of Boron-Bridged Dimethylethylenediamino Bis(boratabenzene) Zirconium(IV) and Iron(II) Complexes
  作者：Arthur J. Ashe、Saleem Al-Ahmad、Xiangdong Fang、Jeff W. Kampf

  DOI：10.1021/om000861g

  日期：2001.2.1

  reaction of 14 with ZrCl4 afforded the boron-bridged dimethylethylenediamino bis(boratabenzene) zirconium dichloride complex 8, while reaction of 14 with FeCl2 afforded the corresponding dimethylethylenediamino-bridged iron(II) complex 9. The structures of 8 and 9 were determined by X-ray diffraction. In each case the boratabenzene units are bridged by an approximately C2-symmetric dimethylethylenediamino

  1-氯-1- boracyclohexadiene（反应12）与N，N- “二甲基-N，N ” -双（三甲硅烷基）乙-1,2-二胺，随后LDA得到的二锂盐N， “ -双（1-硼烷基苯）-N，N′-二甲基亚乙基-1，2-二胺（14）。14与ZrCl 4的反应提供了硼桥连的二甲基乙二氨基双（硼苯苯）二氯化锆配合物8，而14与FeCl 2的反应提供了相应的二甲基乙二氨基桥连的铁（II）配合物9。8和9的结构通过X射线衍射测定。在每种情况下，硼烷苯单元都被约C 2对称的二甲基乙二胺基桥联，形成8和9个手性。通过2D 1 H NOESY确定对映异构体8的相互转化的势垒为21.2±0.2 kcal / mol，而根据可变温度13 C NMR光谱确定为9的相应势垒为16.9±0.5 kcal / mol。这两个势垒都涉及绕环外ππ键的旋转。与相应的桥联的环戊二烯基络合物10和11进行了比较。
• Ureidoacetamido-penicillins
  申请人：Konig; Hans-Bodo

  公开号：US03933795A1

  公开（公告）日：1976-01-20

  6-(.alpha.-3-Acyl-unreidoacetamido)-penicillanic acids and pharmaceutically acceptable non-toxic salts thereof in which the hydrogen atom of the nitrogen atom present in the 3-position is substituted, are effective against Gram-positive and Gram-negative infections, particularly Klebsiella aerobacter infections.

  6-(.alpha.-3-酰基未饱和酰胺基)-青霉烷酸及其药学上可接受的无毒盐，其中氮原子在3位的氢原子被取代，对革兰氏阳性和革兰氏阴性感染有效，特别是对肺炎克雷伯菌感染有效。
• Ureidoacetamido-penicillins for treating bacterial infections
  申请人：Bayer Aktiengesellschaft

  公开号：US03978223A1

  公开（公告）日：1976-08-31

  6-(.alpha.-3-Acyl-ureidoacetamido)-penicillanic acids and pharmaceutically acceptable non-toxic salts thereof in which the hydrogen atom of the nitrogen atom present in the 3-position is substituted, are effective against Gram-positive and Gram-negative infections, particularly Klebsiella aerobacter infections.

  6-(α-3-酰基-尿素乙酰基)-青霉烷酸及其药学上可接受的无毒盐，其中3位氮原子上的氢原子被取代，对革兰氏阳性和革兰氏阴性感染有效，尤其是对克雷伯氏菌感染有效。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sc: MVol.D4, 2.3.2, page 111 - 115
  作者：

  DOI：——

  日期：——