4-amino-1-trityl-1H-pyrazolo[3,4-b]pyridine | 173898-23-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-amino-1-trityl-1H-pyrazolo[3,4-b]pyridine
• 英文别名: 4-amino-1-triphenylmethylpyrazolo[3,4-b]pyridine；1-tritylpyrazolo[3,4-b]pyridin-4-amine
• CAS: 173898-23-2
• 化学式: C₂₅H₂₀N₄
• 分子量: 376.461
• InChiKey: GUUMTWCLTPRLLG-UHFFFAOYSA-N

物化性质

• 沸点：
  610.7±55.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-amino-1-trityl-1H-pyrazolo[3,4-b]pyridine 、 (R)-(1-(N-benzyloxycarbonyl)aminoethyl)-2-nitrobenzoyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-N-(1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)-4-(1-(N-benzyloxycarbonyl)aminoethyl)-2-nitrobenzamide
  参考文献：
  名称：

  US5958944

  摘要：

  公开号：

文献信息

• Amide compounds and use thereof
  申请人：——

  公开号：US20030158413A1

  公开（公告）日：2003-08-21

  The present invention relates to an amide compound of the formula 1 wherein R 1 is a hydrogen and the like, R 2 is a hydrogen and the like, X is SO 2 and the like, Y is the formula (III) and the like and a is 2, an isomer thereof or pharmaceutically acceptable salts thereof. The compound of the present invention shows a remarkable and selective Rho kinase inhibitory action, is free of problematic toxicity, shows fine oral absorption and drug kinetics (absorption, distribution, metabolism, excretion and the like of the drug), and shows superior properties (e.g., stability etc.) as a compound. Accordingly, it can be used as a therapeutic drug for various diseases in which Rho kinase is involved.

  本发明涉及一种式1的酰胺化合物，其中R1为氢等，R2为氢等，X为SO2等，Y为式（III）等，a为2，其异构体或其药学上可接受的盐。本发明的化合物显示出显著且选择性的Rho激酶抑制作用，不具有有毒性问题，显示出良好的口服吸收和药物动力学（药物的吸收、分布、代谢、排泄等），并且显示出优越的特性（例如稳定性等）作为一种化合物。因此，它可以作为治疗涉及Rho激酶的各种疾病的治疗药物。
• N-heterocyclic substituted benzamide derivatives with antihypertensive activity
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1195372A1

  公开（公告）日：2002-04-10

  Benzamide compounds of the formula wherein each symbol is as defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharmaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypotensive action and cerebral • coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.

  苯甲酰胺化合物的化学式如规范中所定义的每个符号，其异构体和药学上可接受的酸盐。包括该化合物的治疗有效量和药学上可接受的添加剂的药物组合物，以及治疗高血压、心绞痛、哮喘、肾脏和外周循环障碍以及脑血管痉挛抑制剂的治疗剂，其中包括该化合物。本发明的化合物具有强大的平滑肌松弛作用，表现出类似于传统钙拮抗剂的降压作用和脑冠脉扩张作用，以及持久的肾脏和外周循环改善作用。与钙拮抗剂不同，它允许口服给药以抑制各种激动剂引起的血管收缩，并可用作冠状动脉、脑部、肾脏和外周动脉循环疾病的预防和治疗的强效长效药物，作为治疗高血压、心绞痛、肾脏和外周循环障碍的治疗剂，脑血管痉挛抑制剂等。此外，本发明的化合物还可用作哮喘的治疗剂。
• BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0757038A1

  公开（公告）日：1997-02-05

  Benzamide compounds of the formula wherein each symbol is as defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharmaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypotensive action and cerebral · coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.

  式中的苯甲酰胺化合物 其中各符号如说明书中所定义，其异构体及其药学上可接受的酸加成盐。包含治疗有效量的本发明化合物和药学上可接受的添加剂的药物组合物，以及包含本发明化合物的高血压治疗剂、心绞痛治疗剂、哮喘治疗剂、肾脏和外周循环障碍治疗剂和脑血管痉挛抑制剂。 本发明的化合物具有很强的平滑肌松弛作用，与传统的钙拮抗剂一样具有降血压作用和脑-冠状动脉血管扩张作用，以及持久的改善肾脏和外周循环的作用。与钙拮抗剂不同的是，它可以通过口服来抑制各种激动剂引起的血管收缩，是一种强效、长效的预防和治疗冠状动脉、脑动脉、肾动脉和外周动脉循环疾病的药物，也是高血压、心绞痛、肾脏和外周循环障碍的治疗药物，还是脑血管痉挛的抑制剂等。此外，本发明的化合物还可用作哮喘的治疗剂。
• AMIDE COMPOUNDS AND USE THEREOF
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1270570A1

  公开（公告）日：2003-01-02

  The present invention relates to an amide compound of the formula wherein R1 is a hydrogen and the like, R2 is a hydrogen and the like, X is SO2 and the like, Y is the formula (III) and the like and a is 2, an isomer thereof or pharmaceutically acceptable salts thereof. The compound of the present invention shows a remarkable and selective Rho kinase inhibitory action, is free of problematic toxicity, shows fine oral absorption and drug kinetics (absorption, distribution, metabolism, excretion and the like of the drug), and shows superior properties (e.g., stability etc.) as a compound. Accordingly, it can be used as a therapeutic drug for various diseases in which Rho kinase is involved.

  本发明涉及一种如下式的酰胺化合物 其中 R1 为氢等，R2 为氢等，X 为 SO2 等，Y 为式（III）等，a 为 2、其异构体或其药学上可接受的盐。本发明的化合物具有显著和选择性的 Rho 激酶抑制作用，无毒性问题，口服吸收和药物动力学（药物的吸收、分布、代谢、排泄等）良好，并显示出作为化合物的优越性能（如稳定性等）。因此，它可以作为一种治疗药物，用于治疗 Rho 激酶参与的各种疾病。
• Substituted benzamide compounds with antihypertensive activity
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1391454A1

  公开（公告）日：2004-02-25

  Benzamide compounds of the formula wherein each symbol is as defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharmaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypotensive action and cerebral·coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.

  式中的苯甲酰胺化合物 其中各符号如说明书中所定义，其异构体及其药学上可接受的酸加成盐。包含治疗有效量的本发明化合物和药学上可接受的添加剂的药物组合物，以及包含本发明化合物的高血压治疗剂、心绞痛治疗剂、哮喘治疗剂、肾脏和外周循环障碍治疗剂和脑血管痉挛抑制剂。 本发明的化合物具有很强的平滑肌松弛作用，与传统的钙拮抗剂一样具有降血压作用和脑-冠状动脉血管扩张作用，以及持久的改善肾脏和外周循环的作用。 与钙拮抗剂不同的是，它可以通过口服来抑制各种激动剂引起的血管收缩，是一种强效、长效的预防和治疗冠状动脉、脑动脉、肾动脉和外周动脉循环系统疾病的药物，也可作为高血压、心绞痛、肾脏和外周循环障碍的治疗药物、脑血管痉挛的抑制剂等。此外，本发明的化合物还可用作哮喘的治疗剂。