2-ethyl-5-propylthiophene | 54244-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-ethyl-5-propylthiophene
• CAS: 54244-74-5
• 化学式: C₉H₁₄S
• 分子量: 154.276
• InChiKey: DXZDTEKFDJNGCS-UHFFFAOYSA-N

物化性质

• 保留指数：
  1099;1120;1122;1120;1123

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-乙基噻吩 在 盐酸 、 磷酸酐 、 amalgamated zinc 作用下， 生成 2-ethyl-5-propylthiophene
  参考文献：
  名称：

  Steinkopf, Justus Liebigs Annalen der Chemie, 1923, vol. 430, p. 104

  摘要：

  DOI：

文献信息

• A Low Rhodium Content Smart Catalyst for Hydrogenation and Hydroformylation Reactions
  作者：Stefano Paganelli、Riccardo Tassini、Vikas D. Rathod、Barbara Onida、Sonia Fiorilli、Oreste Piccolo

  DOI：10.1007/s10562-020-03407-5

  日期：2021.5

  of activity in hydrogenation and hydroformylation reactions of an easily produced 0.18% Rh/Al2O3. Analytical studies on fresh and recycled samples shed light on the smart properties of such catalyst. Results showed high activity as well as fine/excellent chemoselectivity or regioselectivity, characteristics that may suggest a wide range of applicability. The low metal content catalyst 0.18% Rh/Al2O3

  本文描述了一种易于生产的 0.18% Rh/Al2O3 在氢化和加氢甲酰化反应中的制备、广泛表征和活性研究。对新鲜和回收样品的分析研究揭示了这种催化剂的智能特性。结果显示出高活性以及优良/优异的化学选择性或区域选择性，这些特征可能暗示着广泛的适用性。低金属含量催化剂 0.18% Rh/Al2O3 在氢化和加氢甲酰化反应中都非常活跃，因此为有价值的 API 提供中间体，如萘丁美酮和依曲普坦，以及一种带有清新绿色花香的香味，让人想起百合花的香味谷。
• Characterization of initial reaction intermediates in heated model systems of glucose, glutathione, and aliphatic aldehydes
  作者：Tianze Wang、Dawei Zhen、Jia Tan、Jianchun Xie、Jie Cheng、Jian Zhao

  DOI：10.1016/j.foodchem.2019.125482

  日期：2020.2

  moiety helped formation of thiazolidines with cysteinylglycine. The unsaturated aldehydes (E)-2-heptenal and (E,E)-2,4-decadienal exhibited high reactivity against glucose for glutathione, yielding higher levels of intermediate compounds than from glucose. Heating prepared intermediates reversibly released the original aldehydes, which caused various compounds formed by retro-aldol, oxidation, etc. to react

  为了了解脂质降解对肉味风味素的美拉德形成的影响，通过以下方法鉴定了葡萄糖-谷胱甘肽与己醛，（E）-2-庚烯或（E，E）-2,4-癸二烯醛的模型系统中的初始反应中间体HPLC-MS和通过NMR。除Amadori化合物外，还发现了通过将巯基加成到羰基或共轭的烯键上的半缩醛和噻唑烷。所有中间体的浓度随反应时间而增加，而具有谷胱甘肽部分的中间体的降解则有助于半胱氨酰甘氨酸形成噻唑烷。不饱和醛（E）-2-庚醛和（E，E）-2,4-癸二醛对谷胱甘肽显示出对葡萄糖的高反应性，比从葡萄糖中产生更高水平的中间体化合物。加热制备的中间体可逆地释放出原始醛，导致由逆醛醇，氧化等形成的各种化合物与H2S和NH3反应。其中，首次提出了包括3-壬烯-2-酮，2-己酰基呋喃和六个二烷基噻吩（例如2-乙基-5-（1-甲基丁基）噻吩）的形成途径。
• Isoprenyl Compounds and Methods Thereof
  申请人：Stock Jeffry B.

  公开号：US20100184768A1

  公开（公告）日：2010-07-22

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他事项外，本发明提供了新型异戊二烯基化合物，能够有效调节炎症反应，并提供包含这些异戊二烯基化合物的药物、化妆品、化妆品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或症状。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或症状。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或症状以及用于治疗或预防与抑制炎症反应相关的疾病或症状的方法。
• NOVEL ADENINE COMPOUND AND USE THEREOF
  申请人：ISOBE Yoshiaki

  公开号：US20120178743A1

  公开（公告）日：2012-07-12

  An antiallergic agent for topical administration containing an adenine compound of general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X 1 represents oxygen, sulfur, NR 1 (R 1 represents hydrogen or alkyl), or a single bond; Y 1 represents a single bond, alkylene, etc.; Y 2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q 1 and Q 2 represents —COOR 10 (wherein R 10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

  一种用于局部给药的抗过敏剂，包含一种通式（1）的腺嘌呤化合物：[其中环A代表一个6到10个成员的单环或双环芳香烃或一个5到10个成员的单环或双环芳香杂环，其中包含1到3个杂原子，选择自0到2个氮原子，0或1个氧原子和0或1个硫原子；n是0到2的整数；m是0到2的整数；R代表卤素，（未）取代的烷基等；X1代表氧，硫，NR1（R1代表氢或烷基）或单键；Y1代表单键，亚烷基等；Y2代表单键，亚烷基等；Z代表亚烷基；且Q1和Q2中的至少一个代表—COOR10（其中R10代表（未）取代的烷基等），等的药学上可接受的盐。
• HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
  申请人：Arndt Joseph

  公开号：US20120208819A1

  公开（公告）日：2012-08-16

  The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

  本发明提供了作为PDK1抑制剂有用的化合物。本发明还提供了它们的组合物，以及治疗PDK1介导的疾病的方法。

表征谱图