7-(n-butyl)-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 7-(n-butyl)-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane
• 英文别名: 3-n-butyl-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane；7-(n-butyl)-9,9-dimethyl-3,7-diazabicyclo[3,3,1]nonane；3-n-butyl-9,9-dimethyl-3, 7-diazabicyclo[3,3,1]nonane；3-butyl-9,9-dimethyl-3,7-diazabicyclo[3,3,1]nonane；3-butyl-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane
• 化学式: C₁₃H₂₆N₂
• 分子量: 210.363
• InChiKey: OTYXRCFJSSFVRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-(n-butyl)-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane 生成 3-[bis(4-fluorophenyl)methyl]-7-butyl-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane
  参考文献：
  名称：

  SCHON, U.;KEHRBACH, W.;BUSCHMANN, G.;KUHL, U.;ZIEGLER, D.

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Benzyl-7-butyl-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane 生成 7-(n-butyl)-9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane
  参考文献：
  名称：

  SCHON, UWE;KEHRBACH, WOLFGANG;BUSCHMANN, GERD;KUHL, ULRICH;ZIEGLER, DIETE+

  摘要：

  DOI：

文献信息

• 3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds and medicaments
  申请人：Kali-Chemie Pharma GmbH

  公开号：US04906640A1

  公开（公告）日：1990-03-06

  3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds corresponding to the formula: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together form an alkylene chain, and R.sup.4 represents lower alkyl, thienyl, halogen substituted thienyl or a --(CH.sub.2).sub.n --R.sup.5 group, wherein n=0-3 and R.sup.5 is an optionally substituted phenyl group. The compounds are pharmacologically active, particularly in influencing the motility of the stomach.

  3-磺酰基-3,7-二氮杂双环[3,3,1]壬烷类化合物对应的化学式如下：其中R.sup.1为烷基、环烷基烷基或苄基，R.sup.2为氢或较低的烷基，R.sup.3为氢或较低的烷基，或者R.sup.2和R.sup.3一起形成一个亚烷基链，R.sup.4代表较低的烷基、噻吩基、卤代噻吩基或--(CH.sub.2).sub.n --R.sup.5基团，其中n=0-3，R.sup.5是一个可选择取代的苯基团。这些化合物在药理学上具有活性，特别是对胃部的运动有影响。
• Method of diuretic treatment with 3,7-diazabicyclo[3,3,1]nonane compounds
  申请人：Kali-Chemie Pharma GmbH

  公开号：US05164401A1

  公开（公告）日：1992-11-17

  A method of treating a mammal in need of diruetic treatment by administering an effective diuretic amount of a diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compound, diuretic pharmaceutical compositions containing an effective diuretic amount of a diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compound; and previously unknown diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compounds containing an optionally substituted phenylalkyl group in the 3-position.

  治疗需要利尿治疗的哺乳动物的方法是通过给予具有利尿活性的3,7,9,9-四取代3,7-二氮杂双环[3,3,1]壬烷化合物的有效利尿量进行治疗，包含有效利尿量的具有利尿活性的3,7,9,9-四取代3,7-二氮杂双环[3,3,1]壬烷化合物的利尿药物组合物；以及先前未知的具有利尿活性的3,7,9,9-四取代3,7-二氮杂双环[3,3,1]壬烷化合物，其中在3-位置含有可选择取代的苯基烷基基团。
• Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo[2,3-e]quinolizine derivatives
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0524004A1

  公开（公告）日：1993-01-20

  Compounds of the formula wherein:    X and Y are independently hydrogen; hydroxy; lower alkyl of 1-6 carbon atoms; lower alkoxy of 1-6 carbon atoms; or halo; or X and Y when adjacent and taken together are methylenedioxy or ethylene-1,2-dioxy;    R is lower alkyl of 1-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; phenyl or phenyl lower alkyl in which any phenyl group may be optionally substituted by one or two substituents chosen from the group consisting of halo, lower alkyl of 1-4 carbon atoms and lower alkoxy of 1-4 carbon atoms; or -ANHSO₂R¹; wherein A is lower alkylene of 1-6 carbon atoms; and R¹ is lower alkyl of 1-6 carbon atoms or -NR²R³; wherein       R² and R³ are independently hydrogen or lower alkyl of 1-6 carbon atoms, or R² and R³ taken together are cycloalkyl of 3-8 carbon atoms; and    n is 1 or 2;    and the pharmaceutically acceptable salts thereof, are useful as α₂-adrenoceptor antagonists, in particular as peripherally selective α₂ -adrenoceptor antagonists.

  该式化合物中：X和Y分别是氢；羟基；1-6个碳原子的低烷基；1-6个碳原子的低烷氧基；或卤素；或当相邻时一起取为亚甲二氧基或乙烯-1,2-二氧基；R是1-6个碳原子的低烷基；3-8个碳原子的环烷基；苯基或苯基低烷基，其中任何苯基可以选择性地被来自卤素、1-4个碳原子的低烷基和1-4个碳原子的低烷氧基的一种或两种取代基取代；或-ANHSO₂R¹；其中A是1-6个碳原子的低烷基；R¹是1-6个碳原子的低烷基或-NR²R³；其中R²和R³分别是氢或1-6个碳原子的低烷基，或R²和R³一起取为3-8个碳原子的环烷基；n为1或2；以及其药用盐，可用作α₂-肾上腺素受体拮抗剂，特别是外周选择性α₂-肾上腺素受体拮抗剂。
• 3,7-diazabicyclo(3,3,1)nonane compounds and pharmaceutical compositions
  申请人：Kali-Chemie Pharma GmbH

  公开号：US04912113A1

  公开（公告）日：1990-03-27

  3,7-Diazabicyclo[3,3,1]nonane compounds having valuable heart rate-affecting pharmacological properties corresponding to the Formula I: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl, R.sup.2 is lower alkyl, R.sup.3 is lower alkyl, or R.sup.2 and R.sup.3 together form an alkylene chain, and R.sup.4 represents a benzhydryl group, optionally substituted by halogen, lower alkoxy, lower alkyl, hydroxy or trifluoromethyl, or a cinnamyl group optionally substituted by halogen, lower alkyl, lower alkoxy, hydroxy, nitro or trifluoromethyl.

  具有有价值的影响心率药理学特性的3,7-二氮杂双环[3,3,1]壬烷类化合物，对应于公式I： ##STR1## 其中R1是烷基、环烷基烷基或苄基，R2是低碳基，R3是低碳基，或者R2和R3一起形成一个烷基链，而R4代表苯基乙酰基基团，可选地被卤素、低碳氧基、低烷基、羟基或三氟甲基取代，或者是一个肉桂基，可选地被卤素、低碳基、低碳氧基、羟基、硝基或三氟甲基取代。
• 3-Phenyl-3,7-diazabicyclo[3.3.1] nonane compounds, process for preparing them, pharmaceutical compositions containing them and use thereof to inhibit cardiac arrhythmia
  申请人：Solvay Pharmaceuticals GmbH

  公开号：US20030109541A1

  公开（公告）日：2003-06-12

  Pharmacologically active compounds of the general formula I 1 wherein R 1 is an alkyl group with 1-6 carbon atoms or a cycloalkylalkyl group with 4-7 carbon atoms, R 2 is lower alkyl, and R 3 is lower alkyl, or R 2 and R 3 together form an alkylene chain with 3-6 carbon atoms, and R 4 represents a phenyl radical monosubstituted in the ortho or para position by nitro, cyano or lower alkanoyl or disubstituted in the ortho and para positions by nitro, and their physiologically compatible acid addition salts are described.

  一般式I1的药理活性化合物，其中R1是1-6个碳原子的烷基或4-7个碳原子的环烷基烷基；R2是较低的烷基，R3是较低的烷基，或者R2和R3共同形成一个具有3-6个碳原子的亚烷基链；R4代表一个苯基，在邻位或对位上被硝基、氰基或较低的烷酰基单取代，或在邻位和对位上被硝基双取代，描述了它们的生理兼容性酸盐。