acetylene magnesium chloride

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: acetylene magnesium chloride
• 英文别名: Magnesium;acetylene;chloride
• 化学式: C₂H₂*2Cl*Mg
• 分子量: 121.249
• InChiKey: FNOPJDQZBSYMCN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.13
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  acetylene magnesium chloride 、 2-丁基环戊酮 、 正丁基氯化镁 在 ammonium chloride 作用下， 以 四氢呋喃 为溶剂， 生成 1-ethynyl-1-hydroxy-2-butylcyclopentane
  参考文献：
  名称：

  11-(2-Hydroxyethylthio)prostenoic acid E.sub.2 series derivatives

  摘要：

  本披露涉及某些11-(2-羟乙基硫基)-9-酮-前列腺素酸E系列衍生物及其中间体，可用作支气管扩张剂和炎症介质释放抑制剂。

  公开号：

  US04085272A1

文献信息

• 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
  申请人：American Cyanamid Company

  公开号：US04297516A1

  公开（公告）日：1981-10-27

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.

  本发明公开的药物活性前列腺素衍生物属于E、F或A系列，在α链的末端亚甲基碳上有一个取代基，该取代基从以下组中选择：##STR1## 其中R是C.sub.1至C.sub.6烷基，和苯基或苯基，苯基上带有1个或多个取代基，该取代基从以下组中选择：C.sub.1-C.sub.4烷基，OR.sub.16，SR.sub.16，F或Cl，R.sub.16是C.sub.1至C.sub.6烷基。
• 11-(2-Hydroxyethylthio)prostenoic acid E.sub.2 series derivatives
  申请人：American Cyanamid Company

  公开号：US04085272A1

  公开（公告）日：1978-04-18

  This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

  本披露涉及某些11-(2-羟乙基硫基)-9-酮-前列腺素酸E系列衍生物及其中间体，可用作支气管扩张剂和炎症介质释放抑制剂。
• 1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series
  申请人：American Cyanamid Company

  公开号：US04254285A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, di-C.sub.1 -C.sub.4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1## 其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，二C.sub.1 -C.sub.4-烷基氨基，以及苯基或苯基取代物，所述苯基或苯基取代物中取代基选择自C.sub.1 -C.sub.4烷基，OR，SR，F或Cl的组成，其中R如前所定义。
• 1-Hydroxymethyl-1-oxo-prostane derivatives of the E.sub.2 series
  申请人：American Cyanamid Company

  公开号：US04170597A1

  公开（公告）日：1979-10-09

  Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E.sub.2 series.

  拥有E.sub.2系列中1-(羟甲基)-1-氧代-前列酮结构的前列酮的衍生物、类似物和同系物。
• 11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives
  申请人：American Cyanamid Company

  公开号：US04218566A1

  公开（公告）日：1980-08-19

  This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

  这份披露描述了某些11-(2-羟乙基硫基)前列腺酸E和F系列衍生物，以及它们的中间体，可用作支气管扩张剂和炎症介质释放抑制剂。