S-dodecyl 2-(1-ethyl-2,6-dioxopiperidin-4-yl)ethanethioate | 1149347-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: S-dodecyl 2-(1-ethyl-2,6-dioxopiperidin-4-yl)ethanethioate
• CAS: 1149347-52-3
• 化学式: C₂₁H₃₇NO₃S
• 分子量: 383.596
• InChiKey: HKVRLUJOPVZDMF-UHFFFAOYSA-N

物化性质

• 沸点：
  510.4±23.0 °C(predicted)
• 密度：
  1.023±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  79.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  溴乙烷 、 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 在 CO₃^(2-)*2Cs⁽²⁺⁾ 作用下， 以 乙腈 为溶剂， 以96%的产率得到S-dodecyl 2-(1-ethyl-2,6-dioxopiperidin-4-yl)ethanethioate
  参考文献：
  名称：

  Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

  摘要：

  Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-kappa B (nuclear factor-kappa B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.107

文献信息

• Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB
  作者：Yuichi Ishikawa、Miyuki Tachibana、Chino Matsui、Rika Obata、Kazuo Umezawa、Shigeru Nishiyama

  DOI：10.1016/j.bmcl.2009.01.107

  日期：2009.3

  Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-kappa B (nuclear factor-kappa B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone. (C) 2009 Elsevier Ltd. All rights reserved.