(3-bromopropyl)dichloromethylsilane | 18209-82-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (3-bromopropyl)dichloromethylsilane
• 英文别名: methyl(3-bromopropyl)dichlorosilane；3-bromopropylmethyldichlorosilane；(3-bromo-propyl)-dichloro-methyl-silane；(3-Brom-propyl)-dichlor-methyl-silan；Dichlor-methyl-(3-brom-propyl)-silan；3-Bromopropyl-dichloro-methylsilane
• CAS: 18209-82-0
• 化学式: C₄H₉BrCl₂Si
• 分子量: 236.011
• InChiKey: ZZCCSMLWSYAJRV-UHFFFAOYSA-N

物化性质

• 沸点：
  85 °C(Press: 13 Torr)
• 密度：
  1.4685 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (3-bromopropyl)dichloromethylsilane 在 氟硼酸钠 作用下， 以 various solvent(s) 为溶剂， 以80%的产率得到(3-bromopropyl)difluoromethylsilane
  参考文献：
  名称：

  Synthesis of 2-methylidene-1-silacyclohexanes from 2,6-dibromohex-1-ene and polyhalosilanes

  摘要：

  Various 2-methylidene-l-silacyclohexanes were prepared by straightforward syntheses from readily available polychloro- or polyfluorosilanes, magnesium and 2,6-dibromohex-l-ene using Barbier-type conditions or a previously synthesized Grignard reagent. Good yields were obtained considering the low stability of the products in the reaction conditions. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2006.08.061
• 作为产物：
  描述：

  烯丙基二氯甲基硅烷 在 氢溴酸 、 过氧化苯甲酰 作用下， 生成 (3-bromopropyl)dichloromethylsilane
  参考文献：
  名称：

  Mironow, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 1862;engl.Ausg.S.1781

  摘要：

  DOI：

文献信息

• Synthesis and chemistry of the phenoxasilins and dihydro-dibenzo-oxasilepins
  作者：V.H.T. Chang、J.Y. Corey

  DOI：10.1016/s0022-328x(00)83978-9

  日期：1980.5

  sila-functional and carbo-functional phenoxasilins from diphenyl ether and o,o′-dibromodiphenyl ether precursors is described. Tricyclic oxasilepins are formed from o,o′-dibromobenzylphenyl ether by metallation with n-BuLi followed by reaction with dichlorosilanes as well as by ring expansion of an appropriate phenoxasilin. Reactions at the silicon center and at the ring methylene carbon of the oxasilepins are

  从二苯基醚和两个硅杂官能的和羰基官能phenoxasilins的形成ø，ö '-dibromodiphenyl醚前体进行说明。通过与正丁基锂金属化，然后与二氯硅烷反应，以及通过扩环适当的苯氧西林，由邻，邻′-二溴苄基苯基醚形成三环氧杂草醚。报道了在氧杂硅基吡啶的硅中心和在环亚甲基碳上的反应，以及试图生成氧杂硅环素的尝试。
• Silaethene
  作者：N. Auner、J. Grobe

  DOI：10.1016/s0022-328x(00)83695-5

  日期：1980.4

  Monosilacyclobutanes of the type RR′2CH2CH2 are prepared by ring closure reactions of 3-halopropylhalosilanes and by substitution of SiCl containing silacyclobutane rings with organometallic reagents (RMgX, LiR, NaCp). Under optimal experimental conditions yields between 50 and 95% can be obtained by both procedures. Characterization of the compounds is accomplished by analytical (C, H, N) and NMR

  类型RR的Monosilacyclobutanes' 2 CH 2 CH 2由3- halopropylhalosilanes环闭合反应，并通过用含有有机金属试剂（RMGX，LIR，NACP）硅杂环丁烷环的SiCl的取代制备。在最佳实验条件下，两种方法均可获得50％至95％的产率。通过分析（C，H，N）和NMR，IR和质谱研究完成化合物的表征。
• Silipramine and related derivatives
  作者：Joyce Y. Corey、Roberta L. Farrell

  DOI：10.1016/s0022-328x(00)90927-6

  日期：1978.6

  A series of new 10,11-dihydro-5H-dibenzo[b,f]silepins are prepared from the reaction o,o′-dilithiobibenzyl with the chlorosilanes HSiCl3, ClCH2CH2CH2SiCl3, MeSiHCl2 and MeSi(CH2CH2CH2Br)Cl2. The only isolated silepin product produced from HSiCl3 is the spiro derivative. The silepin product produced from MeSiHCl2 reacts with N,N-dimethylallylamine in the presence of H2PtCl6 to give silipramine, a tricyclic

  一系列新的10,11-二氢-5- ħ -二苯并[ b，˚F ] silepins从反应制备ø，ö '与氯硅烷HSiCl -dilithiobibenzyl 3，CLCH 2 CH 2 CH 2的SiCl 3，MeSiHCl 2和MESI （CH 2 CH 2 CH 2 Br）Cl 2。由HSiCl 3产生的唯一分离的silepin产品是螺衍生物。由MeSiHCl 2产生的ilepin产品与N，N反应-二甲基烯丙胺在H 2 PtCl 6的存在下得到西利帕明，一种三环衍生物，与临床上有效的抗抑郁药丙咪嗪有关。由（o -LiC 6 H 4 CH 2）2和MeSi（CH 2 CH 2 CH 2 Br）Cl 2产生的西莱平被转化为二乙氨基丙基衍生物以及不饱和类似物。10-溴-5,5-二甲基-10,11-二氢-5 H-二苯并[ b，f ] silepin与N-甲基哌嗪反应生成10-（N-甲基哌嗪基）取
• Tricyclic systems which contain silicon and nitrogen heteroatoms in central seven- and eight-membered rings
  作者：Joyce Y. Corey、Helen M. Janoski、Delores F. Vermount、Julia P. Paton、Vincent H.T. Chang

  DOI：10.1016/s0022-328x(00)90332-2

  日期：1980.7

  The generation of three tricyclic ring systems which contain both silicon and nitrogen heteroatoms in the central ring are described. Dibenz[b,e][1,4]azasilepines are formed in the reaction of dichlorosilanes with the lithiation product from o-BrC6H4N(CH3)CH2C6H4Br-o and n-BuLi but the direct reaction products could not be purified. Dibenz[b,f][1,4]azasilepines are prepared from the fluoride ion induced

  描述了在中心环中同时包含硅和氮杂原子的三个三环系统的生成。在二氯硅烷与邻溴化锂6 H 4 N（CH 3）CH 2 C 6 H 4 Br- o和n-BuLi的锂化产物的反应中形成Dibenz [ b，e ] [1,4]氮杂环丁烷。直接反应产物无法纯化。Dibenz [ b，f ] [1,4]阿扎西平是由氟离子诱导的菲氮杂啉的膨胀制备的。迪本茨[ c，f] [1,5]氮杂环丁烷是由（o -BrCH 2 C 6 H 4）2 Si（CH 3）2与伯胺反应制得的。还描述了在硅和氮杂原子上都引入二甲基氨基丙基侧链。
• Synthesis of unsaturated organosilicon compounds by the dehydrochlorination of chloro(3-chloroalkyl)silanes
  作者：V. F. Mironov、V. V. Nepomnina

  DOI：10.1007/bf00912049

  日期：1960.12