2-{2-[(t-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetic acid | 250597-84-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-{2-[(t-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetic acid
• 英文别名: (Z)-(2-t-butoxycarbonylamino-5-chloro-thiazol-4-yl)-trityloxyimino-acetic acid；(2Z)-2-[5-chloro-2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,3-thiazol-4-yl]-2-trityloxyiminoacetic acid
• CAS: 250597-84-3
• 化学式: C₂₉H₂₆ClN₃O₅S
• 分子量: 564.062
• InChiKey: KAIOMOJDMYCJEP-SNCSUOKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-{2-[(t-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetic acid 在 吗啉 、 吡啶 、 三氯氧磷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 (6R,7R)-7-{2-(2-tert-Butoxycarbonylamino-5-chloro-thiazol-4-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-chloromethylsulfanyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
  参考文献：
  名称：

  Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens

  摘要：

  The variety of cephalosporins 1 and 2 which possessed C(3)-aminopyrimidinyl substituents were prepared and evaluated for their antibacterial activities. They exhibited excellent in vitro activities especially against respiratory tract pathogens such as penicillin resistant Streptococus pneumonia, Moraxella catarrhalis and Haemophilus influenza. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00425-x
• 作为产物：
  描述：

  (2-Amino-5-chloro-thiazol-4-yl)-[(Z)-hydroxyimino]-acetic acid ethyl ester 在 4-二甲氨基吡啶 、 sodium hydroxide 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-{2-[(t-butoxycarbonyl)amino]-5-chloro-1,3-thiazol-4-yl}-2-[(trityloxy)imino]acetic acid
  参考文献：
  名称：

  Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens

  摘要：

  The variety of cephalosporins 1 and 2 which possessed C(3)-aminopyrimidinyl substituents were prepared and evaluated for their antibacterial activities. They exhibited excellent in vitro activities especially against respiratory tract pathogens such as penicillin resistant Streptococus pneumonia, Moraxella catarrhalis and Haemophilus influenza. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00425-x

文献信息

• [EN] NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME<br/>[FR] NOUVEAUX COMPOSES A BASE DE CEPHALOSPORINE ET PROCEDE DE FABRICATION CORRESPONDANT
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2003072582A1

  公开（公告）日：2003-09-04

  The present invention relates to a novel cephalosporin compound, and pharmaceutically acceptable non-toxic salt, physiologically hydrolysable ester, hydrate, solvate or isomer thereof, to a pharmaceutical composition comprising the compound, and to a process for preparing the compound.

  本发明涉及一种新的头孢菌素化合物，以及其药用可接受的无毒盐、生理可水解酯、水合物、溶剂合物或异构体，还涉及包含该化合物的药物组合物，以及制备该化合物的方法。
• NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME
  申请人：LG CHEMICAL LIMITED

  公开号：EP1077981B1

  公开（公告）日：2002-08-07
• Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens
  作者：Chang-Seok Lee、Eun-Jung Ryu、Seong Ho Oh、Kyoung-Sook Paek、Mu Yong Kim、Hasik Youn

  DOI：10.1016/s0960-894x(00)00425-x

  日期：2000.9

  The variety of cephalosporins 1 and 2 which possessed C(3)-aminopyrimidinyl substituents were prepared and evaluated for their antibacterial activities. They exhibited excellent in vitro activities especially against respiratory tract pathogens such as penicillin resistant Streptococus pneumonia, Moraxella catarrhalis and Haemophilus influenza. (C) 2000 Elsevier Science Ltd. All rights reserved.